Results 71 to 80 of about 304,614 (388)

Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung disease [PDF]

, 2016
Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung ...
Amoroso, Daria, Barbano, Biagio, DI PAOLO, Marcello, Gigante, Antonietta, Palange, Paolo, Romaniello, Antonella, Rosato, Edoardo, Tallerini, Gaia   +7 more
core   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Scalable Production of Highly-Sensitive Nanosensors Based on Graphene Functionalized with a Designed G Protein-Coupled Receptor [PDF]

, 2014
We have developed a novel, all-electronic biosensor for opioids that consists of an engineered mu opioid receptor protein, with high binding affinity for opioids, chemically bonded to a graphene field-effect transistor to read out ligand binding. A variant of the receptor protein that provided chemical recognition was computationally redesigned to ...
arxiv   +1 more source

Neuropeptide Y is up-regulated and induces antinociception in cancer-induced bone pain [PDF]

Neuroscience. 2018 Aug 1;384:111-119. Epub 2018 May 29. PMID: 29852245, 2018
Pain remains a major concern in patients suffering from metastatic cancer to the bone and more knowledge of the condition, as well as novel treatment avenues, are called for. Neuropeptide Y (NPY) is a highly conserved peptide that appears to play a central role in nociceptive signaling in inflammatory and neuropathic pain.
arxiv   +1 more source

BOSENTAN - endothelin receptor antagonist

International Journal of Human and Health Sciences (IJHHS), 2018
Activation of the endothelin system has been demonstrated in the plasma and lung tissue of PAH (Pulmonary Artery Hypertension) patients. Although it is not clear if the increases in endothelin plasma levels are a cause or a consequence of PH (Pulmonary Hypertension), the data supports a prominent role for the endothelin system in the pathogenesis of ...
Paras Passi, Neerja Singal, Kiran Kumar Singal, Nitin Gupta, Gautam Sumit, Mohit Singla   +5 more
openaire   +2 more sources

Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist [PDF]

Cardiovascular Research, 1998
The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evaluate and compare the effects of BQ-123, an ETA
Zhang, Y., Oliver, J., Horowitz, J.
openaire   +4 more sources

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo   +9 more
wiley   +1 more source

Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension

Respiratory Research, 2009
Background In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to increased pulmonary vascular and airway
Borst Mathias M, Bruckner Thomas, Filusch Arthur, Voelkers Mirko, Rohde David, Droste Annette S, Katus Hugo A, Meyer F Joachim   +7 more
doaj   +1 more source

Variation in the use of pulmonary vasodilators in children and adolescents with pulmonary hypertension: a study using data from the MarketScan® insurance claims database

Pulmonary Circulation, 2020
Despite progress in pharmacotherapy in pediatric pulmonary hypertension, real-world patterns of directed pulmonary hypertension therapy have not been studied in the current era.
Michael L. O'Byrne, Jennifer A. Faerber, Hannah Katcoff, David B. Frank, Alex Davidson, Therese M. Giglia, Catherine M. Avitabile   +6 more
doaj   +1 more source

Distinct ETA receptor binding mode of macitentan as determined by site directed mutagenesis. [PDF]

PLoS ONE, 2014
The competitive endothelin receptor antagonists (ERA) bosentan and ambrisentan, which have long been approved for the treatment of pulmonary arterial hypertension, are characterized by very short (1 min) occupancy half-lives at the ET(A) receptor.
John Gatfield, Celia Mueller Grandjean, Daniel Bur, Martin H Bolli, Oliver Nayler   +4 more
doaj   +1 more source