Results 91 to 100 of about 24,688 (303)

Endothelial Cell Dysfunction in Viral Hemorrhage and Edema

Frontiers in Microbiology, 2015
The endothelium maintains a vascular barrier by controlling platelet and immune cell interactions, capillary tone and interendothelial cell adherence.
Erich Reuter Mackow, Elena E Gorbunova, Irina N. Gavrilovskaya   +2 more
doaj   +1 more source

Dendritic cell traffic across lymphatic endothelium under inflammatory conditions [PDF]

, 2012
Objectives: 1. To study the effects of IFNα in DC migration across lymphatic endothelium. 2. To describe some of the mechanisms that underlay the participation of integrins and integrin receptors in DC transendothelial migration across inflamed ...
Rouzaut, A. (Ana), Teijeira, A. (Álvaro), Melero, I. (Ignacio)   +2 more
core  

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α [PDF]

, 2010
Migration of DC into lymphatic vessels ferries antigenic cargo and pro-inflammatory stimuli into the draining LN. Given that tissues under the influence of viral infections produce type I IFN, it is conceivable that these cytokines enhance DC migration ...
Garasa, S. (Saray), Suarez, N. (Natalia), Rouzaut, A. (Ana), Dubrot, J. (Juan), Gonzalez, I. (Iranzu), Alfaro, C. (Carlos), Martinez-Forero, I. (Iván), Teijeira, A. (Álvaro), Palazon, A. (Asís), Hervas-Stubbs, S. (Sandra), Larrea, E. (Esther), Melero, I. (Ignacio)   +11 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Visualization of intrapulmonary lymph vessels in healthy and inflamed murine lung using CD90/Thy-1 as a marker.

PLoS ONE, 2013
BackgroundLymphatic vessels play a pivotal role in fluid drainage and egress of immune cells from the lung. However, examining murine lung lymphatics is hampered by the expression of classical lymph endothelial markers on other cell types, which hinders ...
Sarah Kretschmer, Ina Dethlefsen, Stefanie Hagner-Benes, Leigh M Marsh, Holger Garn, Peter König   +5 more
doaj   +1 more source

Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11 [PDF]

, 2019
Colorectal cancer (CRC) is one of the most malignant tumors worldwide. Stromal cells residing in the tumor microenvironment strongly contribute to cancer progression through their crosstalk with cancer cells and extracellular matrix.
Garlatti V, Correale C., Vetrano S., Malesci A, Spaggiari P, Carvello M., Tacconi C, Correale C, Rubbino F., Vetrano S, Carvello M, Peyrin-Biroulet L, Sacchi M., D'Alessio S, Malesci A., Colombo P., Rasponi M., Danese S, Rubbino F, Spinelli A, Tacconi C., Ungaro F., Peyrin-Biroulet L., Garlatti V., Spaggiari P., Sacchi M, Ugolini GS, Massimino L., Massimino L, Ugolini G. S., Rasponi M, Spano S., Ungaro F, Spano S, D'Alessio S., Spinelli A., Danese S., Colombo P   +37 more
core   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Nestin as a Marker Beyond Angiogenesis—Expression Pattern in Haemangiomas and Lymphangiomas

Biomedicines
Background: The intermediate filament nestin was first described in stem and progenitor cells of neural and mesenchymal origin. Additionally, it is expressed in endothelial cells during wound healing and tumorigenesis.
Andreas Mamilos, Lina Winter, Christoph B. Wiedenroth, Tanja Niedermair, Stefanie Zimmer, Volker H. Schmitt, Karsten Keller, Ondrej Topolčan, Marie Karlíková, Markus Rupp, Christoph Brochhausen, Cristina Cotarelo   +11 more
doaj   +1 more source

Inflammation-induced migration of neutrophils across the lymphatic endothelium [PDF]

, 2011
The lymphatic system provides a conduit for the trafficking of immune cells from the periphery to draining lymph nodes, both for constitutive immune surveillance and during inflammation.
Rigby, David Andrew
core