Results 121 to 130 of about 43,399 (257)

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Meningeal lymphatic-associated brain swelling in acute stroke. [PDF]

PLoS One
Patil RM, Back DB, Hamanaka G, Desai R, Hayakawa A, Chan SJ, Ahn BJ, Pignataro G, Hayakawa K, Esposito E.   +9 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Cutaneous lymphangiosarcoma in an African green monkey from St. Kitts, and a literature review. [PDF]

J Vet Diagn Invest
Bochynska D, Armien A, Harris M, Curtis A, Bolfa P.   +4 more
europepmc   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

The role of the cardiac lymphatic system in heart failure "reverse remodeling": from developmental signals to druggable targets. [PDF]

Front Immunol
Huang T, Qi T, Yao L, Zhu Z, Li C, Tang P, Meng Z, Wen Z, Wang T, Liu S, Xie P, Li Z, Hu J.   +12 more
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Guidelines for evaluating endothelial function in vascular tissue. [PDF]

Am J Physiol Heart Circ Physiol
McCarthy CG, Aalkjær C, Bagher P, Beyer AM, Boedtkjer E, Bomfim GF, Breslin JW, Briones AM, Castorena-Gonzalez JA, Costa TJ, Dai Z, Davel AP, Earley S, Freed JK, Garland C, Isakson BE, Jepps TA, Kalucka J, Lavanderos B, Makino A, Norton CE, Segal SS, Tan W, Trask AJ, Wilson C, Zawieja SD, Wenceslau CF.   +26 more
europepmc   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Aging Theories and Prevention of Age-Related Diseases Using Phytocomplexes. [PDF]

Biology (Basel)
Khanturin MR, Demchenko GA, Koibasova LU, Abdreshov SN, Yessenova MA, Imankulova SK, Akhatayeva YN.   +6 more
europepmc   +1 more source