Results 241 to 250 of about 145,699 (299)

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Recurrent pediatric vesical lymphangioma: The first case report of early relapse after transurethral resection and successful endoscopic management. [PDF]

Urol Case Rep
Bourimi C, Tariqi R, Mesbahi S, Gounni MY, Kibanzala J, Fekkar A, Rais M, Boualaoui I, Ibrahimi A, Nouini Y.   +9 more
europepmc   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities. [PDF]

Front Cell Neurosci
Zhang M, Huang X, Yao L, Wu W.
europepmc   +1 more source

Integrating brain organoids, meningeal immunity, and glymphatic dynamics: toward modeling neuroimmune clearance and crosstalk in disease. [PDF]

Front Immunol
Wu X, Du B, Chen Q, Hang R, Cui C, Li M.
europepmc   +1 more source

Operationalizing perioperative clearance reserve: a reserve-load interaction model for neurocognitive outcomes in older surgical patients. [PDF]

Front Med (Lausanne)
La B, Bai Y, Qiu Y, Wang L.
europepmc   +1 more source

Aerobic Exercise Activates S1PR1 Signaling in Tumor Endothelial Cells to Promote Vascular Function in Pancreatic Cancer. [PDF]

Cancer Res
Ballarò R, Lam T, Pareek S, Lee J, Patel H, Tirumala P, Liu G, Hayek K, Savage H, De Maleki R, Guerrouahen BS, Ngo-Huang A, Parker NH, Katz MHG, Petzel MQ, McAllister F, Wright RD, Roy RA, Abraham RG, Pezeshki K, Tan L, Lorenzi PL, Schadler KL.   +22 more
europepmc   +1 more source

The role of the lymphatic network in colorectal cancer: anatomy, molecular drivers and management. [PDF]

Ann Gastroenterol
Chrysikos D, Taprantzis N, Shihada A, Kanavaros P, Troupis T.   +4 more
europepmc   +1 more source