Results 71 to 80 of about 162,393 (307)
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Financing the Development of Awqaf Property
American Journal of Islam and Society, 1999 This article identifies the various ways in which Islamic endowments helped provide essential services for public welfare during the heyday of Islamic civilization. Four goals are essentially accomplished.
Monzer Kahf
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Asy-Syari'ah, 2018 Penelitian ini menghasilkan dua temuan. Pertama, para ulama madzhab berbeda pendapat tentang hukum wakaf benda bergerak. Para Ulama Hanafiyah, tidak membolehkan wakaf benda bergerak dalam segala bentuknya.
Boedi Abdullah
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
PENGEMBANGAN POTENSI WAKAF DI MASJID AT TAQWA BINUANG KAB TAPIN
At-Taradhi: Jurnal Studi Ekonomi, 2018 Waqaf besides has spiritual values also has social economic values. Indonesia has the potential endowments are very boast. If the potential of waqf is well developed, then it will give good effect to the economy of the society and welfare. Endowments can
Lisda Aisyah
doaj +1 more source
Hedging Pure Endowments with Mortality Derivatives [PDF]
, 2010 In recent years, a market for mortality derivatives began developing as a way to handle systematic mortality risk, which is inherent in life insurance and annuity contracts.
Wang, Ting, Young, Virginia R.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
PENGELOLAAN WAKAF PONDOK PESANTREN AL-HIKMAH SIRAMPOG KABUPATEN BREBES
Inferensi Jurnal Penelitian Sosial Keagamaan, 2017 The purpose of this study is to reveal the waqf management practices in Al-Hikmah Islamic Boarding School and contribution to education and community empowerment, and uncover the factors supporting and managing endowments in the foundation. This research
Edi Setiawan
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source