Results 61 to 70 of about 162,393 (307)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

THE ENDOWMENT EFFECT AS BLESSING [PDF]

International Economic Review, 2018
AbstractWe study the idea that seemingly unrelated behavioral biases can coevolve if they jointly compensate for the errors that any one of them would give rise to in isolation. We suggest that the “endowment effect” and the “winner's curse” could have jointly survived natural selection together. We develop a new family of “hybrid‐replicator” dynamics.
Frenkel, Sivan, Heller, Yuval, Teper, Roee   +2 more
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Wakaf dalam Tafsir Al-Manar (Penafsiran atas Surat al-Baqarah ayat 261-263 dan Ali ‘Imran ayat 92)

Al-tijary, 2016
The Quran does not mention the endowment directly , there is not found the word waqf . Nevertheless , the history of Islam noted , the Prophet never practiced endowments . Likewise with friends Umar bin Khattab .
Nunung Lasmana
doaj   +1 more source

Endowment Effects in Chimpanzees [PDF]

Current Biology, 2007
Human behavior is not always consistent with standard rational choice predictions. Apparent deviations from rational choice predictions provide a promising arena for the merger of economics and biology [1-6]. Although little is known about the extent to which other species exhibit these seemingly irrational patterns [7-9], similarities across species ...
Jones, Owen D., Brosnan, Sarah F., Lambeth, Susan P., Mareno, Mary Catherine, Richardson, Amanda S., Schapiro, Steven   +5 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Challenges and Obstacles to the Development of Endowments in Iran [PDF]

مطالعات وقف و امور خیریه
IntroductionThe Waqf institution has a significant role in the fair distribution of wealth, meeting the social, cultural, economic, and health needs of the society.
Mohammad Javad Valizadeh, Ahmad Reza Hasankhani   +1 more
doaj   +1 more source

Influence of negative interest rates on endowements and foundations functioning [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2015
Negative interest rate exists in the case when on the basis of the deposit contract a deponent is obliged to pay to a depository (a bank) a reimbursement for the money keeping (paying to save).
Nikolić Dušan Ž.
doaj   +1 more source

Preschoolers and the Endowment Effect [PDF]

PLoS ONE, 2014
We show that preschoolers exhibit the endowment effect as evidenced by experiments where children generally chose to keep their own toys rather than trading them for similar ones. Furthermore, we relate the emergence of this effect to children's innate psychobiological traits--emotional state, gender, handedness, and digit ratio.
Da Silva, Sergio, Moreira, Bruno, Da Costa Jr, Newton   +2 more
openaire   +4 more sources