Results 221 to 230 of about 72,488 (260)

Dose-Response Determination in Multistage Endpoint Clinical Trials

Therapeutic Innovation & Regulatory Science, 2014
Improper dose selection remains one of the key drivers of the large attrition rates observed in confirmatory studies in clinical drug development. Many factors contribute to this problem, such as insufficient resources allocated to dose-ranging studies and the use of statistical methods better suited for phase 3 studies than for dose selection.
Fei, Chen, José, Pinheiro
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Determining the Endpoint of a Segment

The Mathematics Teacher, 2001
A new method for determining the coordinates of the endpoint of a line segment, given its slope, point of origin, and length.
openaire   +1 more source

Visual information throughout a reach determines endpoint precision

Experimental Brain Research, 2006
People make rapid, goal-directed movements to interact with their environment. Because these movements have consequences, it is important to be able to control them with a high level of precision and accuracy. Our hypothesis is that vision guides rapid hand movements, thereby enhancing their accuracy and precision. To test this idea, we asked observers
Ma-Wyatt, A., McKee, S.
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An optimization algorithm for determining the endpoints of isolated utterances

ICASSP '81. IEEE International Conference on Acoustics, Speech, and Signal Processing, 2005
This paper describes an optimization technique for locating the initial and final points of utterances. Acoustic parameters extracted from each signal segment are converted into a cost function versus time. An overall cost for the presence of a speech signal is introduced and is to be optimized with respect to the unknown initial and final points.
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A titrimetric determination using laser-beam scattering for endpoint determination

Journal of Chemical Education, 1991
Data from one of four repeated trials of a lecture experiment that determines the stability constant of a silver amine complex.
David W. Brooks, Edward J. Lyons
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A NOMOGRAPH FOR DETERMINING FIFTY PER CENT ENDPOINTS

Journal of Applied Bacteriology, 1961
SUMMARY A universal nomograph is presented for determining the 50% response dose (RD 50 ) from the cumulative percentage response. Instructions are given for the preparation of simpler nomographs for particular test conditions.
H. TINT, ANNE GILLEN
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Method and apparatus for determining the endpoints of a speech utterance

The Journal of the Acoustical Society of America, 1990
A speech utterance is supplied to a control circuit which includes a plurality of band-pass filters and a maximum value detector coupled to the filters. The maximum value of the outputs of the filters are fed to an endpoints-detector wherein the endpoints are located or determined using the maximum value and at least one threshold value.
openaire   +1 more source

Cystic Fibrosis and the Use of Pharmacogenomics to Determine Surrogate Endpoints for Drug Discovery

American Journal of PharmacoGenomics, 2001
Cystic fibrosis (CF) is caused by a mutation in the CFTR gene, encoding a chloride channel. For the most common mutation, Delta F508, the basis of the deficit is the failure of the mutant CFTR channel protein to traffic properly to the apical plasma membrane of the affected epithelial cell.
O, Eidelman, J, Zhang, M, Srivastava, H B, Pollard   +3 more
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Chemical Cleaning Endpoint Determination Using Electrochemical Techniques

CORROSION 1985, 1985
Abstract Theoretically, it is possible to use a measure of voltage difference (ΔE) between an iron electrode and a second electrode to follow the concentration of iron in chemical cleaning solutions, as predicted by the following equation: ΔE=A+Blog[Fe]where A and B are characteristics of the cleaning solvent.
J. V. Monter, J. M. Jevec, G. J. Theus
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Determination of Cell Dose–survival Relationships from Endpoint Dilution Assays

International Journal of Radiation Biology, 1993
Methods for fitting radiation survival curves to data obtained from endpoint-dilution assays are described. It is shown that for functional forms such as the linear-quadratic model the problem can be recast as a generalized linear model (GLM) and the data fitted using standard software.
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