Results 121 to 130 of about 680,453 (333)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Meta-analyses of the effects of high-intensity interval training in elite athletes—part I: mean effects on various performance measures

Frontiers in Physiology
IntroductionMeta-analysts have found that high-intensity interval training (HIIT) improves physical performance, but limited evidence exists regarding its effects on highly trained athletes, measures beyond maximum oxygen uptake (V˙O2max), and the ...
Hans-Peter Wiesinger, Hans-Peter Wiesinger, Hans-Peter Wiesinger, Thomas Leonard Stöggl, Thomas Leonard Stöggl, Nils Haller, Nils Haller, Julia Blumkaitis, Tilmann Strepp, Francesca Kilzer, Anna Schmuttermair, Will G. Hopkins   +11 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Aerobic Endurance Development in 13 and 14 Year-Old Swimmers

Bulletin of the Transilvania University of Braşov: Series IX Sciences of Human Kinetics
In the specialized literature, physical effort is considered a request of the body above the rest level, a stimulus applied in order to adapt. Sporting physical effort determines the modification of homeostasis, stabilizing it in a certain period of time,
C. Tartalranu, D. Ortanescu
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Caffeine Ingestion With or Without Low-Dose Carbohydrate Improves Exercise Tolerance in Sedentary Adults

Frontiers in Nutrition, 2019
Caffeine (CAF) and carbohydrate (CHO) ingestion delay fatigue during prolonged exercise; however, this is primarily documented in endurance trained (ET) athletes. Our purpose was to determine if these ergogenic aids are also effective to improve exercise
Namrita Kumar, Gordon L. Warren, Teresa K. Snow, Melinda Millard-Stafford   +3 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Bearing endurance tests in vacuum for sputtered molybdenum disulfide films [PDF]

Angular-contact, 440C stainless steel, ball bearings with sputtered MoS2 films 0.0000006 x 10-7m (6000 A) thick were evaluated in a vacuum bearing chamber (1750 rpm, 137.9-N- (31-lbf-) thrust load) for endurance.
Spalvins, T.
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Sports Physiology in Adolescent Track-and-Field Athletes: A Narrative Review

Open Access Journal of Sports Medicine, 2023
Pantelis T Nikolaidis,1 Valentine D Son’kin2 1School of Health and Caring Sciences, University of West Attica, Athens, Greece; 2Russian State University of Physical Education, Sport, Youth and Tourism (SCOLIPE), Moscow, RussiaCorrespondence: Pantelis T ...
Nikolaidis PT, Son’kin VD
doaj