Results 101 to 110 of about 258,314 (243)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Eight‐week lat pull‐down resistance training with joint instability leads to superior pull‐up endurance performance and reduced antagonist coactivation in recreationally active male college students

European Journal of Sport Science
This study aimed to investigate the effects of an 8‐week lat pull‐down resistance training program with joint instability on pull‐up performance in male college students.
Qian Li, Jiaqi Yan, Minjie Qiao, Jiuqing Quan, Yiqing Chen, Mingxin Gong, Wenxin Niu, Lejun Wang   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

High‐level performances following low altitude training and tapering in warm environments in elite racewalkers

European Journal of Sport Science
Current guidelines for prolonged altitude exposure suggest altitude levels ranging from 2000 to 2500 m to optimize an increase in total hemoglobin mass (Hbmass). However, natural low altitude locations (
Bastien Krumm, Brent Vallance, Louise Burke, Johan Garcia, Janne Bouten, Franck Brocherie, Jonas J. Saugy, Francesco Botrè, Raphael Faiss   +8 more
doaj   +1 more source

The Comparison of Motoric Characteristics of Young Soccer Players According to Their Playing Positions [PDF]

Sportif Bakış Spor ve Eğitim Bilimleri Dergisi, 2016
The purpose of this study was to compare motoric features, 10-30m speed, agility, flexibility, standing long jump and yo-yo 1 test according to playing position at young soccer players.
Ayşegül Yapıcı, Eray Aydın, Eylem Çelik, Gizem Başkaya   +3 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effect of Lactobacillus acidophilus XY27 in Regulating Intestinal Flora and Enhancing Swimming Endurance

Shipin gongye ke-ji
This study investigated the effects and potential mechanisms of Lactobacillus acidophilus XY27 (LAXY27) on enhancing exercise endurance in mice.
Yanwei ZONG, Canlin SONG, Dehan LUO, Chenxi JIAO   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Cluster analysis as an effective tool for identifying physical fitness in students: the basis for an innovative approach to optimizing physical education in the university environment

Frontiers in Physiology
ObjectiveThis study analyzes university students’ physical fitness and, based on the results, applies cluster analysis to identify homogeneous groups with aim to optimize physical education programs at the university.MethodsA group of 88 first-year ...
Alena Cepková, Richard Cepka, Ľubomír Šooš, Oto Honz, Marián Uvaček, Ján Žiška, Erika Zemková   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source