Results 91 to 100 of about 8,549,940 (285)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The intake of sodium bicarbonate has no effect on end power and work above end power using the 3-min all-out test

Current Issues in Sport Science
Introduction & Purpose Sodium bicarbonate (NaHCO3) is widely used to enhance buffering capacity during high-intensity exercise. However, the negative effects of acidosis, as well as the influence of NaHCO3, remain questionable and controversial.
Valentina Powolny, Christoph Triska, Vanessa Sebestyen-Schreitl, Thomas Pekar, Alfred Nimmerichter   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Multidisciplinary Analysis of Differences Between Finisher and Non-finisher Ultra-Endurance Mountain Athletes

Frontiers in Physiology, 2019
Ultra-endurance races are one of the most physically and psychologically demanding sports, depending performance on several elements. The aims of the present study were (i) to analyze differences in selected psychophysiological parameters between ...
Pedro Belinchón-deMiguel, José Francisco Tornero-Aguilera, Athanasios A. Dalamitros, Pantelis T. Nikolaidis, Pantelis T. Nikolaidis, Thomas Rosemann, Beat Knechtle, Beat Knechtle, Vicente Javier Clemente-Suárez, Vicente Javier Clemente-Suárez   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Speed Endurance Training to Improve Performance [PDF]

Scandinavian Journal of Medicine & Science in Sports
ABSTRACTIn many sports, the physical dimension plays a crucial role in determining athletic performance. This review provides insights into the effectiveness of speed endurance training (SET), that is, exercise training performed at intensities higher than that eliciting maximum oxygen uptake (V̇O2‐max), on performance across different sports and event
Jens Bangsbo, Julie Kissow, Morten Hostrup   +2 more
openaire   +2 more sources

Study on Electrical Behavior of TiO₂ and ZnO Nanostructures: Resistive Switching and State Retention Under Pressure and Temperature Conditions

Nanomaterials
TiO2 nanotubes and ZnO thin films were investigated as oxide-based memristive systems for resistive switching and state-endurance applications under variable environmental conditions.
Cristian E. Patiño, Daniel E. Nuñez, Y. Porras Ramírez, Jorge A. Calderón, Heiddy P. Quiroz, A. Dussan   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Effect of endurance training on lung function: A one year study [PDF]

, 2005
The official published version can be accessed from the link below.Objective: To identify in a follow up study airway changes occurring during the course of a sport season in healthy endurance athletes training in a Mediterranean region.
Connes, P, Godard, P, Godard, P., Robert, Evelyne, Préfaut, Christian, Kippelen, P, Kippelen, Pascale, Robert, E, Prefaut, C, Connes, Philippe, Caillaud, Corinne, Caillaud, C   +11 more
core   +1 more source

Blood flow restriction endurance exercise and endurance performance in athletes

Exercise and Quality of Life
The development and advancement of sports training over time have been accompanied by continuous innovations, which significantly contribute to improving athletic performance.
Matevž Arčon, Nejc Črnčič
doaj   +1 more source