Results 71 to 80 of about 80,760 (262)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Blood flow restriction endurance exercise and endurance performance in athletes
Exercise and Quality of LifeThe development and advancement of sports training over time have been accompanied by continuous innovations, which significantly contribute to improving athletic performance.
Matevž Arčon, Nejc Črnčič
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in Psychology, 2018 Previous studies have suggested that transcranial direct current stimulation (tDCS) might improve exercise performance and alter psychophysiological responses to exercise.
Carlo Baldari +6 more
doaj +1 more source
Performing Clarity, Sincerity, and Endurance
AMA Journal of EthicsHealth beliefs about one's own future should be clearly expressed, sincere, and enduring to be taken seriously by clinicians when assessing risks and benefits in key health decisions. This cartoon considers how clinicians' expressions of doubt about those beliefs can undermine patient-clinician relationships and a patient's epistemic authority.
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Frontiers in Physiology, 2017 Objective: To compare peak oxygen uptake (VO2peak) and the test-retest reliability of physiological parameters between a 1-min and a 3-min closed-end and an incremental open-end upper-body poling test.Methods: On two separate test days, 24 healthy, upper-
Julia K. Baumgart +2 more
doaj +1 more source
Speed Endurance Training to Improve Performance [PDF]
Scandinavian Journal of Medicine & Science in SportsABSTRACTIn many sports, the physical dimension plays a crucial role in determining athletic performance. This review provides insights into the effectiveness of speed endurance training (SET), that is, exercise training performed at intensities higher than that eliciting maximum oxygen uptake (V̇O2‐max), on performance across different sports and event
Jens Bangsbo +2 more
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source