Results 91 to 100 of about 9,670,708 (343)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

THERMAL DECOMPOSITION KINETICS OF AN ENERGY COMPOSITE MATERIAL ON THE BASIS OF INERT BINDING

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2019
The results are presented of the study of thermal decomposition kinetics of the K – 2 model mixed energetic material, the main components of which are ammonium perchlorate, octogen, aluminum and an inert binder, polybutadiene, plasticized with ...
Yu.M. Milekhin, A.A. Koptelov, I.A. Koptelov, A.A. Rogozina   +3 more
doaj   +1 more source

Molecular perovskites as a new platform for designing advanced multi-component energetic crystals

Energetic Materials Frontiers, 2020
Molecular perovskite energetic crystals, as an emerging family of promising practicable energetic materials, have attracted increasing attentions in the past few years.
Wei-Xiong Zhang, Shao-Li Chen, Yu Shang, Zhi-Hong Yu, Xiao-Ming Chen   +4 more
doaj   +1 more source

Light Element Production in the Circumstellar Matter of Energetic Type Ic Supernovae

, 2006
We investigate energetic type Ic supernovae as production sites for Li6 and Be in the early stages of the Milky Way. Recent observations have revealed that some very metal-poor stars with [Fe/H]
Cayrel R., D’Antona F., Ko Nakamura, Meneguzzi M., Nath B. B., Primas F., Primas F., Shinya Wanajo, Spite F., Susumu Inoue, Toshikazu Shigeyama   +10 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Representation of Material Elements and Geometry of Substructural Interactions

, 2007
This paper collects some characteristic aspects of the general model-building framework of the mechanics of complex bodies, that are bodies in which the material substructure influences prominently the gross behavior through interactions conjugated with ...
Mariano, Paolo Maria
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Polynigrogen Energetic Materials

Journal of the Korea Institute of Military Science and Technology, 2016
ABSTRACT Current research trends of prediction of possible structures, synthesis and explosive characteristics of polynitrogen molecules(PNs) are reviewed. Theoretically PNs are composed only of nitrogen atoms, in which N-N bonds are either single or double bonds, and thus when these molecules decompose, release of enormous energy is accompanied.
openaire   +1 more source

Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth [PDF]

, 2020
The outer Solar System object (486958) Arrokoth (provisional designation 2014 MU₆₉) has been largely undisturbed since its formation. We study its surface composition using data collected by the New Horizons spacecraft. Methanol ice is present along with
Grundy, W. M., Keane, J. T.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source