Results 51 to 60 of about 256,217 (299)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Three-dimensional characterization of modifications in sapphire exposed to laser-induced damage using multimodal spectral microimaging

Scientific Reports
Sapphire (Al2O3) is a commonly used dielectric material with many applications in lasers and optical systems. Owing to its high resistivity to laser induced damage, it is particularly suitable for use in high power laser systems.
Raymond P. McBride, Brittany N. Hoffman, Stavros G. Demos, John C. Lambropoulos   +3 more
doaj   +1 more source

Laser-direct-drive program: Promise, challenge, and path forward

Matter and Radiation at Extremes, 2017
Along with laser-indirect (X-ray)-drive and magnetic-drive target concepts, laser direct drive is a viable approach to achieving ignition and gain with inertial confinement fusion.
E.M. Campbell, V.N. Goncharov, T.C. Sangster, S.P. Regan, P.B. Radha, R. Betti, J.F. Myatt, D.H. Froula, M.J. Rosenberg, I.V. Igumenshchev, W. Seka, A.A. Solodov, A.V. Maximov, J.A. Marozas, T.J.B. Collins, D. Turnbull, F.J. Marshall, A. Shvydky, J.P. Knauer, R.L. McCrory, A.B. Sefkow, M. Hohenberger, P.A. Michel, T. Chapman, L. Masse, C. Goyon, S. Ross, J.W. Bates, M. Karasik, J. Oh, J. Weaver, A.J. Schmitt, K. Obenschain, S.P. Obenschain, S. Reyes, B. Van Wonterghem   +35 more
doaj   +1 more source

Comparison of different methods for evaluation of wind turbine power production based on wind measurements

Renewable Energy and Environmental Sustainability, 2016
Investigations of the wind shear up to the height of 200 (m) on the Latvian coast of the Baltic Sea have been carried out using a Pentalum SpiDAR laser measuring complex.
Bezrukovs Valerijs, Zacepins Aleksejs, Bezrukovs Vladislavs, Komasilovs Vitalijs   +3 more
doaj   +1 more source

Numerical Investigation of School Stratified Ventilation Systems - A Ventilation Effectiveness Study [PDF]

E3S Web of Conferences, 2019
Good indoor air quality is an essential prerequisite for a healthy learning environment. Scientific research has shown that there is a direct correlation between air quality and pupils’ ability to learn.
Adili Mohammad Reza, Engstfeld Simon, Stergiaropoulos Konstantinos   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

First-Principles Studies of Local Order in Relaxor Ferroelectrics

, 1998
A key to optimizing the growth of the new single-crystal relaxor ferroelectrics is resolving basic questions concerning their structural properties and energetics.
Krakauer, Henry, Wensell, Mark
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Retracted Article: Road Traffic Monitoring System with Self-Learning Function using the Raspberry Pi Platform [PDF]

MATEC Web of Conferences, 2019
The authors, Cosmin Rus, Răzvan Marcuş and Olimpiu Stoicuța, regret that this article is an accidental duplication of an article that has already been published: https://www.mathworks.com/matlabcentral/fileexchange/52456-analyzing-trafficusing-a-webcam-a-
Rus Cosmin, Marcuş Răzvan, Stoicuța Olimpiu   +2 more
doaj   +1 more source