Results 71 to 80 of about 1,188,556 (260)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
THE ENERGY ISSUES: A CORPUS-BASED ANALYSIS
Romanian Economic Journal, 2015 The energy-related issues have become of paramount importance in recent years due to the exhaustion of fossil fuel resources, their price variations and political dependence on nations with role of energy providers.
Maria-Floriana Popescu
doaj
Reinforcement learning layout‐based optimal energy management in smart home: AI‐based approach
IET Generation, Transmission & DistributionThis research addresses the pressing need for enhanced energy management in smart homes, motivated by the inefficiencies of current methods in balancing power usage optimization with user comfort. By integrating reinforcement learning and a unique column‐
Sajjad Afroosheh +3 more
doaj +1 more source
Optimal control of electric energy quality, based on lexicographic approach
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie ŚrodowiskaImportant components of large and complex energy systems are electric energy supply systems, which perform the function of providing electric energy quality at the clamps of electric energy consumers.
Yurii Voitiuk +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The Impact of Energy Feedback on Occupant Energy Conservation Behavior: an Agent-Based Approach [PDF]
پژوهش در مدیریت تولید و عملیاتPurpose: The purpose of this study is to enhance the effectiveness of energy-saving awareness events by identifying optimal participant selection methods.
Mohammad Zareie +2 more
doaj +1 more source