Results 81 to 90 of about 1,188,556 (260)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Wind Energy Integration through District Heating. A Wind Resource Based Approach

Resources, 2015
The aim of this paper is to examine if the surplus of wind energy could be added to electricity-to-heat conversion systems when there is increased congestion in the grid or when there is wind power curtailment.
George Xydis
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Machine Learning Approach to Climate‐Based Building Energy Consumption

Energy Science & Engineering
This study proposes a data‐driven framework to assess the impact of climatic parameters on building energy consumption across three diverse Iranian cities: Tehran (semi‐arid), Bandar Abbas (hot‐humid), and Rasht (humid‐moderate).
Ali Maboudi Reveshti, Farid Hosseini Mansoub, Jhila Nasiri Reveshti, Karim Farajeyan Bonab   +3 more
doaj   +1 more source

Transformer-Based Approach for Predicting Transactive Energy in Neurorehabilitation

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Advancements in robotic neurorehabilitation have made it imperative to enhance the safety and personalization of physical human-robot interactions (pHRI).
Naveed Ahmad Khan, Tanishka Goyal, Fahad Hussain, Prashant K. Jamwal, Shahid Hussain   +4 more
doaj   +1 more source

The nonlinearity of helical springs: An energy-based approach

American Journal of Physics
A general expression for the elastic potential energy of a helical spring is derived using the basic concepts of elasticity theory and geometry. Both the translational and the rotational displacement of the spring's moving ends are considered. The resulting expression is employed to derive the general relation between force and spring height, and ...
Saša Ilijić, Ana Babić, Dora Ivrlač, Andrew DeBenedictis   +3 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Generating Renewable Energy Based on the Circuit Approach

, 2023
In this study, a new methodology based on the circuit approach is employed to obtain renewable electric energy. Although a voltage source and a current source generate voltage and current, respectively, they work only when they receive electric power, which is the product of voltage and current.
openaire   +1 more source