Results 71 to 80 of about 9,473,807 (397)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Crashworthiness performance of the designed concave hexagonal structures as filler element in cylindrical shells in multiple load cases

open access: yesFracture and Structural Integrity, 2023
Safety Impact resistance is defined as the ability of a material to absorb impact energy through a controlled failure mechanism. The greater the energy absorption by the crash safety structure, the greater the safety in preventing deformation of the main
Andre Hartawan Mettanadi   +4 more
doaj   +1 more source

Spectroscopic evidences of quantum critical charge fluctuations in cuprates

open access: yes, 2006
We calculate the optical conductivity in a clean system of quasiparticles coupled to charge-ordering collective modes. The absorption induced by these modes may produce an anomalous frequency and temperature dependence of low-energy optical absorption in
Abanov   +17 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Research into energy absorption of liquid cabin subjected to close-range explosion

open access: yesZhongguo Jianchuan Yanjiu, 2017
In order to study the energy absorption of different parts of a liquid cabin under a close-range explosion, a fluid-structure coupling model is built on the basis of experiments, and the deformation of the bulkhead and energy absorption ratio of ...
LI Siyu   +3 more
doaj   +1 more source

Investigation of Impulse Aging of Energy-Absorption Elements for Hybrid DC Circuit Breakers [PDF]

open access: gold, 2023
Xinyi Wang   +6 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Ultrahigh Energy Absorption Multifunctional Spinodal Nanoarchitectures

open access: yesSmall, 2019
AbstractNanolattices are promoted as next‐generation multifunctional high‐performance materials, but their mechanical response is limited to extreme strength yet brittleness, or extreme deformability but low strength and stiffness. Ideal impact protection systems require high‐stress plateaus over long deformation ranges to maximize energy absorption ...
Anna Guell Izard   +4 more
openaire   +3 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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