Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
All-Silicon Energy Storage (ASES)
, 2015 31st European Photovoltaic Solar Energy Conference and Exhibition; 80 ...
Datas Medina, Alejandro +3 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Open source all-iron battery for renewable energy storage
HardwareX, 2019 The price of renewable energy is dropping rapidly. Energy storage will be needed to take full advantage of abundant but intermittent energy sources. Even with economies of scale, the price is prohibitively high for a lithium-ion battery pack capable of ...
Nicholas Yensen, Peter B. Allen
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Neutrino energy loss from the plasma process at all temperatures and densities [PDF]
, 1993 Eric Braaten, Daniel J. Segel
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Abundance of Low Energy Cosmic Ray Boron and Nitrogen Nuclei Measured at Voyager 1 Beyond the Heliopause, Where Do They All Come From? An Interpretation Using a Leaky Box Galactic Propagation Model [PDF]
, 2015 W. R. Webber
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
All-Day Thermogalvanic Cells for Environmental Thermal Energy Harvesting
Research, 2019 Direct conversion of the tremendous and ubiquitous low-grade thermal energy into electricity by thermogalvanic cells is a promising strategy for energy harvesting. The environment is one of the richest and renewable low-grade thermal source.
Boyang Yu +9 more
doaj +1 more source