Results 51 to 60 of about 8,436,065 (295)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Campbell Systematic ReviewsBackground Halfway through the final decade of actions towards the 2030 Sustainable Development Goals (SDGs), progress toward SDG7 is off track. It is estimated that by 2030, 660 million people, mainly rural populations within Sub‐Saharan Africa, will be
Cem Yavuz +9 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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All-Optical control of linear and nonlinear energy transfer via Zeno effect
, 2018 Microresonator-based nonlinear processes are fundamental to applications including microcomb generation, parametric frequency conversion, and harmonics generation.
Guo, Xiang +3 more
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Structural Mechanics of Engineering Constructions and Buildings, 2021 Relevance. In recent years, composite materials have become widespread in the construction of reinforced concrete structures for industrial, civil and transport structures.
Oleg D. Rubin +2 more
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Gravitational vacuum polarization IV: Energy conditions in the Unruh vacuum
, 1997 Building on a series of earlier papers [gr-qc/9604007, gr-qc/9604008, gr-qc/9604009], I investigate the various point-wise and averaged energy conditions in the Unruh vacuum.
B. P. Jensen +24 more
core +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Sustainable energy for all [PDF]
, 2015 The idea of ‘sustainable energy for all’ has been built around three key objectives, ‘ensuring universal access to modern energy services, doubling the global rate of improvement in energy ef ciency and doubling the share of renewable energy in the global energy mix‘ (UN, 2012). The rst of these three objectives is most relevant for this chapter.
World Bank, International Energy Agency
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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