Results 71 to 80 of about 22,054,072 (293)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Unlocking High Fluoride‐Ion Conductivity by Regulating the Order–Disorder Transition in Bi‐substituted PbSnF4

Small Structures
Layered fluorite‐type tetragonal β‐PbSnF4 exhibits the highest fluoride‐ion conductivity among solid electrolytes; however, its room‐temperature performance is limited by a phase transition to the low‐conductivity monoclinic α‐PbSnF4, and guidelines for ...
Saito Itakura, Naoki Matsui, Kazuhiro Mori, Takashi Saito, Fangzhou Song, Seungyub Song, Keisuke Shimizu, Kota Suzuki, Ryoji Kanno   +8 more
doaj   +1 more source

All-optical seasonal energy saving windows

iScience
Summary: Adaptive thermal regulation is crucial for year-round energy savings in buildings, especially in mid-latitude regions. Here, leveraging the seasonally varying angles of direct sunlight, we report a microprism-array sheet that enables seasonal ...
Beom-Su Kim, Jae-Hyun Kim, Gumin Kang, Hyungduk Ko, Qiaoqiang Gan, Sun-Kyung Kim   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The effect of gluon condensate on the DC conductivity and butterfly effect

Physics Letters B
In this work, we study the effect of gluon condensate on the DC conductivity and butterfly effect using AdS/CFT. First, by considering the butterfly velocity defined by the metric, we find that the butterfly velocity decreases with the increase of gluon ...
Jing Zhou, Saiwen Zhang
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Energy/Delay Tradeoffs in All-Spin Logic Circuits

IEEE Journal on Exploratory Solid-State Computational Devices and Circuits, 2016
All-spin logic (ASL) is a spin-based candidate for implementing logic in the next generation designs. The energy and the delay of ASL circuits are both inherently related to the geometric parameters of ASL gates, and the careful selection of the ...
Zhaoxin Liang, Sachin S. Sapatnekar
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source