Results 71 to 80 of about 2,539,572 (302)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Energy and land use in the Pamir-Alai Mountains [PDF]

, 2011
In a comparative study of energy resources and energy consumption patterns in the Pamir-Alai Mountains of Kyrgyzstan and Tajikistan, the relations between energy consumption, land use, and livelihoods were investigated.
Förster, Heidi, Pachova, Nevelina I., Renaud, Fabrice G.   +2 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Pursuing More Sustainable Consumption by Analyzing Household Metabolism in European Countries and Cities [PDF]

, 2005
Bringing about more sustainable consumption patterns is an important challenge for society and science. In this article the concept of household metabolism is applied to analyzing consumption patterns and to identifying possibilities for the development ...
Biesiot, Bin, Bullard, Bullard, Carlsson-Kanyama, Carlsson-Kanyama, Carlsson-Kanyama, Charlotte Clark, Clark, Cohen, Engelenburg, Falkena, Harald Throne-Holst, Henri C. Moll, Herendeen, Kim, Klaas Jan Noorman, Kok, Kok, Lenzen, Moll, Munksgaard, Nonhebel, Noorman, Pachauri, Rebecka Engström, Reinders, Rixt Kok, Throne-Holst, Vringer, Wiersma   +30 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Energy consumption and capacity utilization of galvanizing furnaces

, 2004
An explicit equation leading to a method for improving furnace efficiency is presented. This equation is dimensionless and can be applied to furnaces of any size and fuel type for the purposes of comparison.
Ackermann W., Bablik H., Blakey S., Blakey S., Cengel Y. A., Costa A., Fagg D. N., Haarmann R., Krzywicki J., Meunier C., Nizzola I., Rhine J. M., Sarkar K. K., Srinivasan P. R., Thring M. W., Wubbenhorst H.   +15 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Environmental and Economic Benefits of Waste Heat Recovery as a Symbiotic Scenario in Sweden

Energies
This study pioneers a combined Life Cycle Assessment (LCA) and Life Cycle Costing (LCC) evaluation of an industrial symbiosis (IS) case involving waste heat recovery from a pulp and paper mill to a tomato greenhouse in Sweden.
María Dolores Mainar-Toledo, Irene González García, Hector Leiva, Jack Fraser, Danna Persson, Thomas Parker   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Physical Assessment of the Mineral Capital of a Nation: The Case of an Importing and an Exporting Country

Resources, 2015
Intensified mineral consumption and reserve depletion means that it is becoming increasingly important for policymakers to account for and manage national mineral capital.
Guiomar Calvo, Alicia Valero, Luis Gabriel Carmona, Kai Whiting   +3 more
doaj   +1 more source