Results 51 to 60 of about 992,380 (312)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Energy consumption of buildings and urban energy poverty assessment: case study of a Madrid neighbourhood. [PDF]

, 2022
The assessment of the energy consumption of buildings is essential in analysing energy poverty. Current indicators in Spain are based on real consumption.
Gallego Sánchez-Torija, Jorge, Fernández Nieto, María Antonia   +1 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A framework for characterising energy consumption of machining manufacturing systems [PDF]

Energy consumption in machining manufacturing systems is increasingly of interest due to concern for global climate change and manufacturing sustainability.
Liu, Xuehui, He, Yan, Yan, Ping, Li, Yufeng, Wang, Yan   +4 more
core   +1 more source

SOFIAS – Herramienta para el análisis de ciclo de vida y la calificación ambiental de edificios

Informes de la Construccion, 2016
Este artículo describe el proceso de desarrollo de la nueva herramienta informática SOFIAS (Software de Funciones Integradas para una Arquitectura Sostenible), financiado por el Ministerio de Economía y Competitividad del Gobierno de España.
X. Oregi Isasi, J. A. Tenorio, C. Gazulla, I. Zabalza, D. Cambra, S. O. Leao, L. Mabe, S. Otero, J. Raigosa   +8 more
doaj   +1 more source

Fossil Fuel and Biofuel Boilers in Ukraine: Trends of Changes in Levelized Cost of Heat

Energies, 2022
An increase in the share of renewables in heat supply systems is a promising direction to reach sustainable development goals and decarbonization. Decision makers should consider various factors, including energy market prices, the availability of ...
Valentyna Stanytsina, Volodymyr Artemchuk, Olga Bogoslavska, Artur Zaporozhets, Antonina Kalinichenko, Jan Stebila, Valerii Havrysh, Dariusz Suszanowicz   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source