Results 121 to 130 of about 1,388,181 (313)

All-optical structuring of laser-driven proton beam profiles

Nature Communications, 2018
Shaping particle beams generated from laser-plasma accelerators is challenging. Here the authors demonstrate an all-optical method to structure the accelerated proton beam by modulating and imprinting the spatial laser profile onto the proton beam.
Lieselotte Obst-Huebl, Tim Ziegler, Florian-Emanuel Brack, João Branco, Michael Bussmann, Thomas E. Cowan, Chandra B. Curry, Frederico Fiuza, Marco Garten, Maxence Gauthier, Sebastian Göde, Siegfried H. Glenzer, Axel Huebl, Arie Irman, Jongjin B. Kim, Thomas Kluge, Stephan D. Kraft, Florian Kroll, Josefine Metzkes-Ng, Richard Pausch, Irene Prencipe, Martin Rehwald, Christian Roedel, Hans-Peter Schlenvoigt, Ulrich Schramm, Karl Zeil   +25 more
doaj   +1 more source

Wormholes with Low Energy Density

Journal of Applied Mathematics and Physics
In spite of their speculative nature, traversable wormholes are a topic of interest that started with the Einstein-Rosen bridge in 1935 and became a major research area with the introduction of the Morris-Thorne wormhole in 1988. It is also become apparent in time that such wormholes are likely to be compact stellar objects, akin to neutron stars ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Trimodal mediated superior sintering and fracture resistance mechanism in nano-metal interconnection

Materials & Design
Understanding the densification mechanisms and mechanical failure behavior of trimodal-sized nano-metal materials under pressure-assisted sintering is critical for developing high-reliability interconnects in advanced power electronics packaging.
Weishan Lv, Suhang Wei, Jiaxin Liu, Jianwei Lv, Jiming Yang, Yuan Zhang, Cai Chen, Yong Kang   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

DBDCC: Density based Distorted Circle Clustering for Energy Efficient Wireless Sensor Networks

peer reviewedWith the rise of the Internet of Things and the need for sustainable large-area monitoring, energy-efficient wireless sensor networks (WSNs) have become a necessity.
Devmurari, Kandarp, Kumar, Manish, RAJPUT, Kunwar   +2 more
core   +1 more source

Interfacial effect of Cu electrode enhanced energy density of amorphous aluminum oxide dielectric capacitor

, 2020
In this work, a novel dielectric system of Cu/amorphous aluminum oxide/Pt (Cu/AmAO/Pt) is developed for dielectric capacitor applications. The high breakdown strength (425 MV m−1), high dielectric constant (8.6) and improved leakage current density are ...
Su, Zhen, Li, Chunyu, Yao, Manwen, Yao, Xi, Li, Zaifang, Wang, Hao   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source