Results 131 to 140 of about 1,388,181 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dietary energy density and energy intake in cancer patients

, 2012
Background & Aims: Cachexia is frequent in advanced cancer and is associated with adverse outcomes; however, definite diagnostic criteria for cachexia are not established. Diet energy density (ED) may affect energy intake (EI) and energy balance. Patient
Wallengren, Ola
core  

New lead-free chemistry for in-situ monitoring of advanced nuclear power plant

Advanced Powder Materials
Nuclear power is essential for sustainable energy infrastructure and economic development, necessitating materials for high-radiation environments that can facilitate visualization and observation.
Lexing Liang, Xiuling Wang, Cong Zhang, Kailei Lu, Guangfan Tan, Yanhao Dong, Yanli Shi, Jianqi Qi, Tiecheng Lu   +8 more
doaj   +1 more source

Room temperature broadband terahertz gains in graphene heterostructures based on inter-layer radiative transitions

AIP Advances, 2014
We exploit inter-layer radiative transitions to provide gains to amplify terahertz waves in graphene heterostructures. This is achieved by properly doping graphene sheets and aligning their energy bands so that the processes of stimulated emissions can ...
Linlong Tang, Jinglei Du, Haofei Shi, Dongshan Wei, Chunlei Du   +4 more
doaj   +1 more source

Energy and Nutrient Density

EDIS, 2011
Foods for the older adult that has lost weight should target both energy and nutrient density. This 1-page fact sheet provides explanation and examples. Written by Wendy J. Dahl and Lauren Foster and published by the UF Department of Food Science and Human Nutrition, May 2011. FSHN11-12/FS176: Energy and Nutrient Density (ufl.edu)
Wendy J. Dahl, Lauren Foster
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of lower hybrid wave injection on edge localized modes in the HL-3 tokamak

Nuclear Fusion
Experiments assessing edge localized mode (ELM) control with lower hybrid wave (LHW) injection were carried out in the newly operational HL-3 tokamak for the first time, and the experimental results demonstrated that ELMs could be effectively suppressed ...
Y.M. Zhang, S.Y. Chen, N. Wu, X.Y. Bai, G.L. Xiao, Y.R. Zhu, Y. Zhou, X.X. He, W.P. Guo, F. Zhang, M.L. Mou, T.Q. Liu, N. Yang, X. Lu, T.Y. Wang, A.S. Liang, Z.B. Shi, C.J. Tang, W.L. Zhong   +18 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source