Results 81 to 90 of about 1,052,656 (265)

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Average energy density and the size of the Universe

Physical Review D, 1987
This paper shows that there is a relationship between the maximum volume of any cosmological solution of the Einstein equations and its average energy density. An inequality is derived which shows that the average energy density multiplied by the volume to the (2/3 power must be greater than a fixed constant.
openaire   +3 more sources

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Critical Point Fluctuations in Heavy-Ion Collisions within Molecular Dynamics with Expansion [PDF]

EPJ Web of Conferences
We analyze particle number fluctuations near the critical endpoint of a first-order phase transition using molecular dynamics simulations of the Lennard-Jones fluid. Building on our previous study [V.A. Kuznietsov et al., Phys. Rev. C 105, 044903 (2022)],
Kuznietsov Volodymyr A., Vovchenko Volodymyr, Koch Volker, Gorenstein Mark I.   +3 more
doaj   +1 more source

Wormholes with Low Energy Density

Journal of Applied Mathematics and Physics
In spite of their speculative nature, traversable wormholes are a topic of interest that started with the Einstein-Rosen bridge in 1935 and became a major research area with the introduction of the Morris-Thorne wormhole in 1988. It is also become apparent in time that such wormholes are likely to be compact stellar objects, akin to neutron stars ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Trimodal mediated superior sintering and fracture resistance mechanism in nano-metal interconnection

Materials & Design
Understanding the densification mechanisms and mechanical failure behavior of trimodal-sized nano-metal materials under pressure-assisted sintering is critical for developing high-reliability interconnects in advanced power electronics packaging.
Weishan Lv, Suhang Wei, Jiaxin Liu, Jianwei Lv, Jiming Yang, Yuan Zhang, Cai Chen, Yong Kang   +7 more
doaj   +1 more source