Results 61 to 70 of about 1,388,181 (313)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Energy densities in quantum mechanics
QuantumQuantum mechanics does not provide any ready recipe for defining energy density in space, since the energy and coordinate do not commute. To find a well-motivated energy density, we start from a possibly fundamental, relativistic description for a spin-12 particle: Dirac's equation. Employing its energy-momentum tensor and going to the non-relativistic
Varazdat Stepanyan +1 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Fluctuating Density Energy Model for RNA Nucleobase Interactions
, 2023 A new potential termed the Fluctuating Density (FD) model is presented as an alternative to traditional fixed partial-charge force fields for describing RNA nucleobase interactions within a molecular mechanics framework.
Alan, Chen, Christopher, Myers
core +1 more source
A comparative study of bridged 1,2,4-oxazolones and their derivatives
Energetic Materials Frontiers, 2020 For energetic compounds, a slight difference in their molecular structures can result in a tremendous difference in their properties. Compounds with similar structures but exhibiting big difference in their physicochemical properties (such as density and
Teng Fei +3 more
doaj +1 more source
Symmetry energy and density [PDF]
Proceedings of 54th International Winter Meeting on Nuclear Physics — PoS(BORMIO2016), 2016 10 pages, 4 figures, talk presented at the 54th International Winter Meeting on Nuclear Physics, 25-29 January 2016, Bormio ...
Trautmann, Wolfgang +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Tunable Plasmonic Bandwidth Broadening via DC Electrical Bias
NanomaterialsThe ability to broaden the bandwidth of nanodevices holds significant promise for applications in modern science and technology. In this work, we demonstrate a tunable approach to the bandwidth modulation of nanoresonators by applying a direct current ...
Chen Wei, Fuhua Gao, Fan Yang
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source