Results 121 to 130 of about 14,184,159 (383)

Non-Gaussian states by conditional measurements

open access: yes, 2009
We address realistic schemes for the generation of non-Gaussian states of light based on conditional intensity measurements performed on correlated bipartite states.
Allevi, Alessia   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Implementation of Selected Spectrum Sensing Systems for Cognitive Radio Networks using FPGA Platform

open access: yesJournal of Telecommunications and Information Technology, 2018
The energy efficient spectrum sensing method is very important in cognitive radio (CR), since high power drain may limit its implementation in mobile applications.
Hikmat N. Abdullah, Hadeel S. Abed
doaj   +1 more source

Nanoscale Quantum Calorimetry with Electronic Temperature Fluctuations

open access: yes, 2018
Motivated by the recent development of fast and ultra-sensitive thermometry in nanoscale systems, we investigate quantum calorimetric detection of individual heat pulses in the sub-meV energy range.
Brange, F.   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

A new large area MCP-PMT for high energy detection. [PDF]

open access: yesSci Rep, 2023
Chen L   +9 more
europepmc   +1 more source

Underwater Acoustic Detection of Ultra High Energy Neutrinos

open access: yes, 2005
We investigate the acoustic detection method of 10^18-20 eV neutrinos in a Mediterranean Sea environment. The acoustic signal is re-evaluated according to dedicated cascade simulations and a complex phase dependant absorption model, and compared to ...
Aguilar   +35 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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