Results 91 to 100 of about 3,622,281 (260)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

5G green cellular networks considering power allocation schemes

, 2015
It is important to assess the effect of transmit power allocation schemes on the energy consumption on random cellular networks. The energy efficiency of 5G green cellular networks with average and water-filling power allocation schemes is studied in ...
Chen, Jiaqi, Ge, Xiaohu, Thompson, John, Wang, Cheng-xiang, Zhang, Jing   +4 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Energy dependence and efficiency [PDF]

Power resources ; Petroleum industry and ...
Jack L. Hervey
core  

The Optimal Size of Stochastic Hodgkin-Huxley Neuronal Systems for Maximal Energy Efficiency in Coding of Pulse Signals

, 2013
The generation and conduction of action potentials represents a fundamental means of communication in the nervous system, and is a metabolically expensive process.
Liu, Liwei, Yu, Lianchun
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Defining a sustainable supply chain for buildings Off-Site envelope thermal insulation solutions: proposal of a methodology to investigate opportunities based on a context analysis

Logistics, Supply Chain, Sustainability and Global Challenges
External wall thermal insulation is one of the most effective solutions on the market to increase energy efficiency in the built environment. Off-Site Construction (OSC), through better control of the various parameters involved, can bring important ...
Benedetti Miriam, Herce Carlos, Sforzini Matteo, Susca Tiziana, Toro Claudia   +4 more
doaj   +1 more source

Lessons Learned and Next Steps in Energy Efficiency Measurement and Attribution: Energy Savings, Net to Gross, Non-Energy Benefits, and Persistence of Energy Efficiency Behavior [PDF]

, 2009
This white paper examines four topics addressing evaluation, measurement, and attribution of direct and indirect effects to energy efficiency and behavioral programs: Estimates of program savings (gross); Net savings derivation through free ridership ...
Colby, Jane, Khawaja, M. Sami, Skumatz, Lisa A   +2 more
core  

Efficiency of Energy Conversion in Thermoelectric Nanojunctions

, 2009
Using first-principles approaches, this study investigated the efficiency of energy conversion in nanojunctions, described by the thermoelectric figure of merit $ZT$. We obtained the qualitative and quantitative descriptions for the dependence of $ZT$ on
Baheti K., Beebe J. M., Chen Y. C., Chen Y. C., Chen Y. C., Cuevas J. C., Di Ventra M., Dubi Y., Finch C. M., Galperin M., Kaun C. C., Ke S. H., Kobayashi N., Lang N. D., Lang N. D., Liu Y. S., Ludoph B., Ma C. L., Malen J. A., Markussen T., Patton K. R., Paulsson M., Pauly F., Reddy P., Smit R. H. M., Tao N. J., Thygesen K. S., Wang B., Wang W., Wold D. J., Yang Z., Zhao J., Zheng X.   +32 more
core   +1 more source