Results 71 to 80 of about 848,604 (282)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
On the optimal energy efficiency and spectral efficiency trade-off of CF massive MIMO SWIPT system
EURASIP Journal on Wireless Communications and Networking, 2021 Energy efficiency is a key requirement for future network design, and user-centric (UC) cell-free (CF) massive multi-input multi-output (MIMO) networks can achieve over ten times the energy efficiency.
Na Li, Yuanyuan Gao, Kui Xu
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
COMPARISON OF ENERGY EFFICIENCY INDEX OF THE SMALL SPEED FERRY AND THE PASSENGER VEHICLE
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015 The information about the energy efficiency of various technical devices, at present, is a necessary knowledge to design new and upgraded equipment.
Mykola M. Konotopets +1 more
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Developing Future UK Energy Performance Standards: The St Nicholas Court project, Final Report [PDF]
, 2003 The St Nicholas Court Project was set up to explore the implications of an enhanced energy performance standard for new housing for the design, construction and performance of timber framed dwellings.
Bell, M, Lowe, RJ, Roberts, D
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Maritime energy management system (MariEMS) online delivery platform [PDF]
, 2017 Maritime accounts for approximately 90% of trade in the world today. The maritime transport is responsible for polluting the atmosphere and the forecast of new scenarios about the shipping emissions predicts an increase between 50% and 250% by 2050 ...
Bhuiyan, Zakirul +3 more
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