Results 91 to 100 of about 2,591,056 (296)
, 2017 We study the energy transfer properties of three dimensional homogeneous and isotropic turbulence where the non-linear transfer is altered in a way that helicity is made sign-definite, say positive.
Biferale, Luca +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
BuildingsThe surrounding rocks of roadways are typically subjected to cyclic loading–unloading stress states in underground engineering. In addition, cyclic loads are discontinuous under real working conditions, usually while loading rock mass in a cycle ...
Ning Jiang +5 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Study on mechanical properties of rock and soil mass in the slip zone of shibanping landslide
Frontiers in Earth ScienceThe mechanical behavior of landslide rock masses and slip zone soils plays a crucial role in the initiation and evolution of landslides, particularly under prolonged rainfall conditions, where the saturation process leads to strength degradation and ...
Meiben Gao +19 more
doaj +1 more source
The evolution of high energy accelerators [PDF]
AIP Conference Proceedings, 1991 The history of high energy accelerators is chronicled. The physical principles of the cyclotron are described, as are those of betatrons, synchrocyclotrons, synchrotrons, colliding beam accelerators, and heavy ion accelerators, comments about the physics learned from these machines are given.(AIP)
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Energy Science & EngineeringDeep coal‐rock formations are subjected to complex stress environments characterized by high static stresses and dynamic disturbances. To study the damage, fracture, and energy evolution characteristics of coal‐rock under dynamic–static combined loading,
Wei Li +8 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source