Results 91 to 100 of about 2,592,144 (295)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Damage and Deterioration Characteristics of Sandstone Under Multi-Stage Equal-Amplitude Intermittent Cyclic Loading and Unloading

Buildings
The surrounding rocks of roadways are typically subjected to cyclic loading–unloading stress states in underground engineering. In addition, cyclic loads are discontinuous under real working conditions, usually while loading rock mass in a cycle ...
Ning Jiang, Yangyang Zhang, Zhiyou Gao, Genwang Zhang, Quanlin Feng, Chao Gong   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Study on mechanical properties of rock and soil mass in the slip zone of shibanping landslide

Frontiers in Earth Science
The mechanical behavior of landslide rock masses and slip zone soils plays a crucial role in the initiation and evolution of landslides, particularly under prolonged rainfall conditions, where the saturation process leads to strength degradation and ...
Meiben Gao, Meiben Gao, Meiben Gao, Meiben Gao, Binbin He, Wenhui Li, Wanjia Guo, Wanjia Guo, Shiming Bai, Lijuan Wang, Lijuan Wang, Lijuan Wang, Rui Bian, Rui Bian, Liang Zhang, Zhihao He, Zhihao He, Zhihao He, Zhihao He, Feng Lu   +19 more
doaj   +1 more source

The evolution of high energy accelerators [PDF]

AIP Conference Proceedings, 1991
The history of high energy accelerators is chronicled. The physical principles of the cyclotron are described, as are those of betatrons, synchrocyclotrons, synchrotrons, colliding beam accelerators, and heavy ion accelerators, comments about the physics learned from these machines are given.(AIP)
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Deformation, fracture, and energy evolution characteristics of coal‐rock under dynamic–static combined loading

Energy Science & Engineering
Deep coal‐rock formations are subjected to complex stress environments characterized by high static stresses and dynamic disturbances. To study the damage, fracture, and energy evolution characteristics of coal‐rock under dynamic–static combined loading,
Wei Li, Zhizhen Zhang, Yeqi Teng, Hao Wang, Cao Man, Menghan Ren, Xiaoji Shang, Linming Dou, Feng Gao   +8 more
doaj   +1 more source

Influence law of abnormal coal thickness zone on coal and gas outburst

Meitan xuebao
Coal and gas outburst is the most serious dynamic disaster threatening the safety production of coal mines in China. The abnormal area of coal thickness is an important factor affecting the occurrence of coal and gas outburst.
Jupeng TANG, Zhonghua ZHANG, Yishan PAN, Lingran REN, Xin ZHANG, Lei HUANG   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Study on the mechanical properties of limestone materials with different moisture contents under cyclic loading and unloading

Frontiers in Materials
IntroductionIn order to reduce the impact of secondary disasters caused by the instability of rock and soil mass (RSM) during engineering construction on the environment, and to achieve safe and efficient engineering construction.
Tingkai Hou, Zonghong Zhou, Jing Zhang, Yonggang Zhang   +3 more
doaj   +1 more source