Results 71 to 80 of about 8,290,976 (301)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Mechanical Properties and Energy Evolution of Granite Under Graded Constant-Amplitude Cyclic Loading

Applied Sciences
To clarify the mechanical response and energy evolution of granite under cyclic disturbance in underground engineering, triaxial graded constant-amplitude cyclic loading–unloading tests were carried out under confining pressures of 6–15 MPa.
Xiaofei Wang, Tuoyu Cheng
doaj   +1 more source

An Energy Preservation Index for Evaluating the Rockburst Potential Based on Energy Evolution

Energies, 2020
The estimation of rockburst potential has attracted great attention in the field of rock mechanics and engineering. In this study, an original energy preservation index is proposed to evaluate the rockburst potential in view of the energy evolution ...
Lin Gao, Feng Gao, Yan Xing, Zhizhen Zhang   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Study on fracture law and energy evolution characteristics of inclined thick-hard roof

Meikuang Anquan
Fracture of the inclined thick-hard roof structure is the direct cause of dynamic disasters such as rock burst. To clarify the fracture law and energy evolution characteristics of the inclined thick-hard roof, taking the 1303 working face with inclined ...
Jinliang ZHANG, Weiping SHI, Shouqing YAN, Guohui WANG, Lei HOU, Jie GUO, Qiongxiang TIAN, Chenshuo ZHANG   +7 more
doaj   +1 more source

Synthetic hybrids of six yeast species

Nature Communications, 2020
Many industrial organisms are the result of recent or ancient allopolypoidy events. Here the authors iteratively combine the genomes of six yeast species to generate a viable hybrid.
David Peris, William G. Alexander, Kaitlin J. Fisher, Ryan V. Moriarty, Mira G. Basuino, Emily J. Ubbelohde, Russell L. Wrobel, Chris Todd Hittinger   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Fracture Mechanics and Strata Pressure Responses in Underground Mining Excavations Induced by Prefabricated Cracks

Geosciences
Rock fracture mechanics and the associated energy-release behavior play a key role in ensuring safe extraction in underground coal mining. Hydraulic fracturing generates prefabricated fracture networks in competent rock strata, thereby modifying fracture
Rui Gao, Chenxi Zhang, Weichen Gao, Guorui Feng, Xiao Huang, Xueming Zhang, Hong Guan   +6 more
doaj   +1 more source

Characteristics of energy storage and dissipation of coal under one‐time cyclic load

Energy Science & Engineering, 2020
Energy is an important research parameter in rock mechanics. To explore the law of energy evolution of coal, a one‐time loading and unloading test under uniaxial compression was conducted on coal taken from four different coal mines.
Kang Peng, Shaowei Shi, Quanle Zou, Junhui Mou, Jin Yu, Yongjiang Zhang, Yanying Cheng   +6 more
doaj   +1 more source