Results 61 to 70 of about 8,290,976 (301)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Energy and damage analysis of fractured sandstone under true triaxial cyclic loading
Meikuang AnquanExploring the energy evolution of fractured sandstone under true triaxial cyclic loading is helpful to clarify the law of rock damage and failure. The evolution characteristics of total absorbed energy, elastic energy, dissipated energy and plastic ...
Xiyuan LI +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BuildingsThe surrounding rocks of roadways are typically subjected to cyclic loading–unloading stress states in underground engineering. In addition, cyclic loads are discontinuous under real working conditions, usually while loading rock mass in a cycle ...
Ning Jiang +5 more
doaj +1 more source
, 1941 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Study on mechanical properties of rock and soil mass in the slip zone of shibanping landslide
Frontiers in Earth ScienceThe mechanical behavior of landslide rock masses and slip zone soils plays a crucial role in the initiation and evolution of landslides, particularly under prolonged rainfall conditions, where the saturation process leads to strength degradation and ...
Meiben Gao +19 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Applied SciencesIn this study, the thick, hard roof group of the 20103 working face in the Dahaize Coal Mine is used as the research object. UDEC discrete element simulations were conducted to examine fracture-induced energy release characteristics under unweakened ...
Xiaolong Shi +5 more
doaj +1 more source
Experimental and numerical study of the evolution of stored and dissipated energies in a medium carbon steel under cyclic loading [PDF]
, 2013 Lien vers la version éditeur: http://www.sciencedirect.com/science/article/pii/S0167663613000288To obtain robust estimations of the fatigue limit from energy-based fatigue criteria, constitutive laws must include a correct description of the energy ...
MOREL, Franck +2 more
core +1 more source