Results 111 to 120 of about 2,592,144 (295)

Classification criteria for coal bursting liability based on scratch testing

Meitan kexue jishu
The bursting liability is an inherent property of coal-rock masses prone to impact failure, serving as an intrinsic factor for coal mines to induce rockburst accidents and a critical indicator for assessing the risk of rockburst. However, the traditional
Yixin ZHAO, Tao WANG, Zhe YANG, Ronghuan XIE   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Damage characteristics and energy storage evolution law of coal with pressure relief borehole

Meitan kexue jishu
In the environment of deep strong mining-induced stress, phenomena such as borehole collapse, closure and compaction are prone to occur in large-diameter pressure relief boreholes in coal seams, and the pressure relief effect shows obvious time-effect ...
Yanchun YIN, Tongbin ZHAO, Aiwen WANG, Chuanru YAO, Fangrui LIU, Xuepeng GAO   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evolution Law of Stress Field and Pressure Relief Effect of Coal Seam After Drilling

Energy Science & Engineering
As an effective means of coal burst prevention, large‐diameter drilling pressure relief technology have been widely used in coal burst mines in China. Engineering practice shows that drilling pressure relief has obvious time‐effect.
Yanchun Yin, Chuanru Yao, Yueyong Han, Yue Qiu, Changqing Li, Yang Chen   +5 more
doaj   +1 more source

Acoustic Emission and Infrared Radiation Energy Evolution in the Failure of Phosphate Rock: Characteristics and Damage Modeling

Applied Sciences
Accurately characterizing the energy evolution during rock failure is crucial in understanding instability mechanisms and enabling the real-time monitoring and early warning of geological hazards in mining and geotechnical engineering.
Manqing Lin, Xuan Peng, Ye Chen, Qi Liao, Xianglong Lu, Xiqi Liu   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Mechanisms and influential factors of rock bursts in tunneling roadways of extra-thick coal seams

Meitian dizhi yu kantan
ObjectiveRock bursts occur frequently in tunneling roadways of extra-thick coal seams, significantly constraining safe coal mining. Investigating their mechanisms and influential factors is crucial to preventing and controlling such disasters in ...
Yujie PENG, Qiang WANG, Anye CAO, Chengchun XUE, Guowei LYU, Qi HAO, Yaoqi LIU, Xianxi BAI, Dong LI   +8 more
doaj   +1 more source