Results 61 to 70 of about 1,107,923 (314)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Nano-Micro LettersHighlights BiOCl atomic layers (BOCNSs-i) were prepared by exfoliating hydrothermally synthesized BiOCl (BOCNSs) via ultrasonication in isopropanol for efficient photocatalytic CO2 overall splitting to CO and O2.
Ting Peng +8 more
doaj +1 more source
Energy flows, metabolism and translation [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 Thermodynamics provides an essential approach to understanding how living organisms survive in an organized state despite the second law. Exchanges with the environment constantly produce large amounts of entropy compensating for their own organized state.
Pascal, Robert, Boiteau, Laurent
openaire +3 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
E3S Web of Conferences, 2018 This paper details the development of a systematic methodology to integrated life cycle assessment (LCA) with thermo-economic models and to thereby identify the optimal exploitation schemes of geothermal resources. Overall geothermal systems consist of a
Matuszewska Dominika +2 more
doaj +1 more source
Submersible Generator for Marine Hydrokinetics [PDF]
, 2011 A submersible generator was designed as a distinct and critical subassembly of marine hydrokinetics systems, specifically tidal and stream energy conversion. The generator is designed to work with both vertical and horizontal axis turbines.
Cinq-Mars, Robert S. +5 more
core +1 more source
, 2001 11 pages, Latex, to appear in NATO ASI volume, ``Structure Formation in the Universe'', ed. R. Crittenden, V.
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Modelling tidal energy extraction in a depth-averaged coastal domain
, 2010 An extension of actuator disc theory is used to describe the properties of a tidal energy device, or row of tidal energy devices, within a depth-averaged numerical model This approach allows a direct link to be made between an actual tidal device and its
M.L.G. Oldfield +12 more
core +1 more source