Results 81 to 90 of about 3,509,597 (298)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Energy efficient continuous flow ash lockhopper [PDF]
, 1989 The invention relates to an energy efficient continuous flow ash lockhopper, or other lockhopper for reactor product or byproduct. The invention includes an ash hopper at the outlet of a high temperature, high pressure reactor vessel containing heated ...
Collins, Earl R., Jr. +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Energies, 2019 One of the most important sources of air pollution, especially in urban areas, is the exhaust emissions from passenger cars. New European emissions regulations, to minimize the gap between manufacturer-reported emissions and those emitted on the road ...
Timothy Bodisco, Ali Zare
doaj +1 more source
Passive swimming in low Reynolds number flows
, 2010 The possibility of microscopic swimming by extraction of energy from an external flow is discussed, focusing on the migration of a simple trimer across a linear shear flow.
J. Happel, Piero Olla
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Kolmogorov turbulence, Anderson localization and KAM integrability
, 2012 The conditions for emergence of Kolmogorov turbulence, and related weak wave turbulence, in finite size systems are analyzed by analytical methods and numerical simulations of simple models.
A. Pikovsky +53 more
core +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Cogeneration – development and prospect in Polish energy sector
E3S Web of Conferences, 2017 Next 10-15 years are crucial for condition of Polish energy sector in light of challenges arising mainly from increasing demand for electric energy, need of reducing greenhouse gases emissions and shutdowns of old units.
Matuszewska Dominika +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source