Results 111 to 120 of about 6,290,398 (299)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Southern African orography impacts on low clouds and the Atlantic ITCZ in a coupled model

open access: yesGeophysical Research Letters, 2017
We examine the influence of southern African orography on the Namibian stratocumulus deck, the South Atlantic ocean‐to‐atmosphere energy transport, and the Intertropical Convergence Zone (ITCZ), using an atmosphere‐only model and a coupled atmosphere ...
S. F. Potter   +2 more
doaj   +1 more source

Energy release and seismic flux

open access: yesAnnals of Geophysics, 1965
From the basic data and tlie previous results of priorpapers, we have made evaluations of the energy released and studied itsvariation. Its pulsative form is confirmed, which suggests several superposedperiods, perhaps of simple multiples of tlie ...
J. M. Munuera
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Energies of quantum QED flux tubes [PDF]

open access: yesJournal of Physics A: Mathematical and General, 2006
9 pages latex, Talk presented at the QFEXT 05 workshop in Barcelona, Sept. 2005.
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Promotion of Efficient Use of Energy: Final Report

open access: yes, 2006
The Department of Energy funded the Alliance to Save Energy to promote the efficient use of energy under a multiyear cooperative agreement. This funding allowed the Alliance to be innovative and flexible in its program development, and to initiate and ...
Alliance to Save Energy (U.S.)
core   +1 more source

Influence of non-thermal electrons on energy transport in temperature-anisotropic Cairns-distributed space plasmas

open access: yesJournal of Taibah University for Science
The energy transport of the circularly polarized electromagnetic (EM) waves is studied in a collisionless Cairns distributed plasmas, whose constituents are mobile electrons and static ions.
Tajammal H. Khokhar   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Energy Flux Through the Magnetopause During Flux Transfer Events in Hybrid-Vlasov 2D Simulations. [PDF]

open access: yesGeophys Res Lett, 2022
Ala-Lahti M   +4 more
europepmc   +1 more source

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