Results 91 to 100 of about 7,545,365 (346)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Outage probability for a multiuser NOMA-based network using energy harvesting relays
Nonlinear Engineering, 2022 This article evaluates the energy-harvesting capabilities of a multiuser non-orthogonal multiple access-based system, where energy harvesting relays utilise the power splitting relaying protocol to harvest energy and amplify-and-forward protocol to ...
Press Rifqah, Balyan Vipin
doaj +1 more source
A rotational switched-mode water-based triboelectric nanogenerator for mechanical energy harvesting and vehicle monitoring [PDF]
, 2022 Chau Duy Le +4 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Fluid-solid-electric lock-in of energy-harvesting piezoelectric flags
, 2014 The spontaneous flapping of a flag in a steady flow can be used to power an output circuit using piezoelectric elements positioned at its surface. Here, we study numerically the effect of inductive circuits on the dynamics of this fluid-solid-electric ...
Doare, Olivier +2 more
core +4 more sources
Hybrid metrology for nanometric energy harvesting devices [PDF]
, 2023 Lauryna Šiaudinytė +4 more
openalex +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
Movers and Shakers: Kinetic Energy Harvesting for the Internet of Things [PDF]
, 2014 Numerous energy harvesting wireless devices that will serve as building blocks for the Internet of Things (IoT) are currently under development. However, there is still only limited understanding of the properties of various energy sources and their ...
Cong, Mina +5 more
core
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source