Results 61 to 70 of about 162,209 (266)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Effect of repair welding location and number of welds performed on creep strength of Mod. 9Cr-1Mo steel welded joints

Nihon Kikai Gakkai ronbunshu
It is planned that Mod.9Cr-1Mo steel will be used as the structural material for the steam generator of the demonstration fast reactor. Creep strength of welded joints of Mod.9Cr-1Mo steel is lower than that of base metal at high temperature and long ...
Hayato YAMASHITA, Kodai TOYOTA, Takashi ONIZAWA, Kenji YAMAMOTO, Koji KUBO   +4 more
doaj   +1 more source

Effect of Swirl Inflow on Flow Pattern and Pressure Fluctuation onto a Single-Elbow Pipe in Japan Sodium-Cooled Fast Reactor

Journal of Fluid Science and Technology, 2012
As part of the development of a flow-induced vibration evaluation methodology for the primary cooling piping in Japan sodium-cooled fast reactor, important factors were discussed in evaluating the flow-induced vibration for the hot-leg piping.
Hidemasa YAMANO, Hiromi SAGO, Kazuo HIROTA, Satoshi HAYAKAWA, Yang XU, Masaaki TANAKA, Takaaki SAKAI   +6 more
doaj   +1 more source

Future Applications of Biotechnology to the Energy Industry [PDF]

Frontiers in Microbiology, 2016
There has been a dramatic growth in the production of biofuels in recent times. Global biofuel production tripled between 2000 and 2007, and biofuels accounted for about 1.6% of global transportation fuel in 2012 (International Energy Agency). At the time of this writing, 2015, ethanol production is by far the greatest contribution by biotechnology to ...
John Joseph Kilbane, John Joseph Kilbane
openaire   +3 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development of a Methodology for Obtaining Solid Models of Products That Are Objects of Reverse Engineering Using the Example of the Capstone Micro-GTU C 65

Modelling
Currently, about a thousand micro gas turbine units of small and medium capacity are in operation in the Russian Federation, which are used as an autonomous power source at critical infrastructure facilities.
Sergey Osipov, Ivan Komarov, Olga Zlyvko, Andrey Vegera, George Gertsovsky   +4 more
doaj   +1 more source

Experimental Investigation on Transient Pressure Characteristics in a Helico-Axial Multiphase Pump

Energies, 2019
In oil and gas exploitation, the multiphase pump is a vital piece of equipment to guarantee production with high efficiency and stable operation. The complicated pattern of multiphase flow in the multiphase pump affects the pump performance; for this ...
Yun Xu, Shuliang Cao, Takeshi Sano, Tokiya Wakai, Martino Reclari   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source