Results 111 to 120 of about 3,973,142 (304)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The Effect of Submerged Vanes on Improving Hydraulic Jump Characteristics and Investigating the Role of Attack Angle [PDF]
علوم آب و خاکOne of the ways to improve the characteristics of the hydraulic jump in the stilling basin is to use natural and artificial roughness. Recently, due to the advantages of immersed plates compared to other non-continuous artificial roughness, such as the ...
M. Heidarpour +2 more
doaj
Non-Abelian Energy Loss at Finite Opacity
, 2000 A systematic expansion in opacity, $L/\lambda$, is used to clarify the non-linear behavior of induced gluon radiation in quark-gluon plasmas. The inclusive differential gluon distribution is calculated up to second order in opacity and compared to the ...
B. G. Zhakharov +20 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Parton energy loss, saturation, and recombination at BRAHMS
, 2005 Particle production as observed with the BRAHMS experiment at RHIC is presented. Preliminary baryon/meson ratios and nuclear modification factors at different rapidities will be discussed.Comment: 5 pages, 4 figures, Lake Louise Winter Institute 2005 ...
Kim, Eun-Joo
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Energy loss of ions by electric-field fluctuations in a magnetized plasma
, 2011 The results of a theoretical investigation of the energy loss of charged particles in a magnetized classical plasma due to the electric field fluctuations are reported. The energy loss for a test particle is calculated through the linear-response theory.
Deutsch, Claude, Nersisyan, Hrachya B.
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source