Results 61 to 70 of about 3,318,639 (335)

Municipal Energy Management: Best Practices from DVRPC's Direct Technical Assistance Program [PDF]

, 2016
This guide highlights best practices and lessons learned from municipal energy management projects in southeastern Pennsylvania. In 2013 and 2014, DVRPC worked with nine municipalities in southeastern Pennsylvania to provide direct technical assistance ...

core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optimized Energy Management Strategy for Wind Plants with Storage in Energy and Reserve Markets [PDF]

, 2019
This paper addresses the joint operation of wind plants with energy storage systemsin multiple markets to increase the value of wind energy from an economic and technical point of view.
Eguia López, Pablo, Gaztañaga, Haizea, González Garrido, Amaia, Saez de Ibarra, Andoni, Villarreal, Igor   +4 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Effects of two pre-workout supplements on concentric and eccentric force production during lower body resistance exercise in males and females: a counterbalanced, double-blind, placebo-controlled trial

Journal of the International Society of Sports Nutrition, 2017
Background Pre-workout supplements purportedly enhance feelings of energy, reduce fatigue and improve exercise performance. The purpose of this study was to examine the performance effects of caffeinated and non-caffeinated multi-ingredient pre-workout ...
Grant M. Tinsley, Matthew A. Hamm, Amy K. Hurtado, Austin G. Cross, Jose G. Pineda, Austin Y. Martin, Victor A. Uribe, Ty B. Palmer   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Dark Energy Survey Data Management System

, 2008
The Dark Energy Survey collaboration will study cosmic acceleration with a 5000 deg2 griZY survey in the southern sky over 525 nights from 2011-2016. The DES data management (DESDM) system will be used to process and archive these data and the resulting ...
Barkhouse, Wayne, Beldica, Cristina, Bertin, Emmanuel, Cai, Y. Dora, da Costa, Luiz, Darnell, J. Anthony, Daues, Gregory E., Gower, Michelle, Jarvis, Michael, Kuropatkin, Nikolay, Lin, Huan, Martelli, leandro, Mohr, Joseph J., Neilsen, Eric, Ngeow, Chow-Choong, Ogando, Ricardo, Parga, Alex, Sheldon, Erin, Stoughton, Chris, Tucker, Douglas   +19 more
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Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Drivers, opportunities, and barriers, for adoption of Maritime Autonomous Surface Ships (MASS)

Journal of International Maritime Safety, Environmental Affairs, and Shipping
The introduction of Maritime Autonomous Surface Ships (MASS) into the maritime transport sector has significantly accelerated, as illustrated by the growth of project prototypes and by academic research throughput.
Anas S. Alamoush, Aykut I. Ölçer, Fabio Ballini   +2 more
doaj   +1 more source