Results 91 to 100 of about 8,597,032 (385)
Metabolic cost as an organizing principle for cooperative learning [PDF]
arXiv, 2012 This paper investigates how neurons can use metabolic cost to facilitate learning at a population level. Although decision-making by individual neurons has been extensively studied, questions regarding how neurons should behave to cooperate effectively remain largely unaddressed.
arxiv
Energy metabolism in ALS: an underappreciated opportunity?
Acta Neuropathologica, 2018 Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal neurodegenerative disorder that primarily affects motor neurons. Despite our increased understanding of the genetic factors contributing to ALS, no effective treatment is ...
T. Vandoorne +2 more
semanticscholar +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Detecting the Escherichia coli metabolic backbone [PDF]
arXiv, 2014 The heterogeneity of reaction fluxes present in a metabolic network within a single flux state can be exploited to construct the so-called backbone as a reduced version of metabolism. The backbone maintains all significant fluxes producing or consuming metabolites while displaying a substantially decreased number of interconnections and, hence, it ...
arxiv
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
Frontiers in Endocrinology, 2016 The adipose tissue is a central metabolic organ in the regulation of whole-body energy homeostasis. The white adipose tissue functions as a key energy reservoir for other organs, whereas the brown adipose tissue accumulates lipids for cold-induced ...
S. S. Choe +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Global and regional brain metabolic scaling and its functional consequences [PDF]
BMC Biology 5:18 (2007), 2007 Background: Information processing in the brain requires large amounts of metabolic energy, the spatial distribution of which is highly heterogeneous reflecting complex activity patterns in the mammalian brain. Results: Here, it is found based on empirical data that, despite this heterogeneity, the volume-specific cerebral glucose metabolic rate of ...
arxiv
A Spatially Distributed Model of Brain Metabolism Highlights the Role of Diffusion in Brain Energy Metabolism [PDF]
arXiv, 2022 The different active roles of neurons and astrocytes during neuronal activation are associated with the metabolic processes necessary to supply the energy needed for their respective tasks at rest and during neuronal activation. Metabolism, in turn, relies on the delivery of metabolites and removal of toxic byproducts through diffusion processes and ...
arxiv
Maturation of Cardiac Energy Metabolism During Perinatal Development
Frontiers in Physiology, 2018 As one of the highest energy consumer organ in mammals, the heart has to be provided with a high amount of energy as soon as its first beats in utero. During the development of this organ, energy is produced within the cardiac muscle cell depending on ...
J. Piquereau, R. Ventura-clapier
semanticscholar +1 more source
Tetrahydrobiopterin in energy metabolism and metabolic diseases
Pharmacological Research, 2020 Tetrahydrobiopterin (BH4) is an endogenous cofactor for various enzymatic conversions of essential biomolecules including nitric oxide, tyrosine, dopamine, serotonin and phenylalanine. Depending on the physiological functions of these molecules, BH4 plays multiple roles in the cardiovascular, immune, nervous and endocrine systems.
Jin Han, Hyoung Kyu Kim
openaire +3 more sources