Results 81 to 90 of about 6,255,996 (283)

Cable Tension of Long-Span Steel Box Tied Arch Bridges Based on Radial Basis Function-Support Vector Machine Optimized by Quantum-Behaved Particle Swarm Optimization

Applied Sciences
To investigate hanger force during the construction phase of large-span steel box tie arch bridges, the challenge of low accuracy in force identification due to multifactor coupling was addressed.
Hongcai Shi, Menglin Shi, Weisheng Xu
doaj   +1 more source

Easy orientation of diblock copolymers on self-assembled monolayers using UV irradiation

, 2009
A simple method based on UV/ozone treatment is proposed to control the surface energy of dense grafted silane layers for orientating block copolymer mesophases. Our method allows one to tune the surface energy down to a fraction of a mN/m.
Jean Daillant, Pang-Hung Liu, Pascal Thébault, Patrick Guenoun   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Gravitational Energy Problem for Cosmological Models in Teleparallel Gravity

, 2010
We present a method to calculate the gravitational energy when asymptotic boundary conditions for the space-time are not given. This is the situation for most of the cosmological models.
Maluf, J. W., Neto, J. F. da Rocha, Ulhoa, S. C.   +2 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The discrete energy method in numerical relativity: Towards long-term stability

, 2004
The energy method can be used to identify well-posed initial boundary value problems for quasi-linear, symmetric hyperbolic partial differential equations with maximally dissipative boundary conditions.
Alcubierre M, Anderson M Matzner R A, Arnowitt R, Babiuc M Szilagyi B Winicour J, Calabrese G, Calabrese G, Calabrese G Lehner L Reula O Sarbach O Tiglio M, Christodoulou D, David Neilsen, Friedrich H, Friedrich H, Gundlach C, Gustaffsson B, Kerr R P, Kidder L E, Klainerman S Rodnianski I, Kreiss H-O, Lax P D, Lehner L, Levy D, Luis Lehner, Manuel Tiglio, Olsson P, Olsson P, Olsson P, Oscar Reula, Reula O, Sarbach O Tom M, Scheel M, Scheel M A, Schnetter E, Shoemaker D, Thornburg J, Tiglio M Lehner L Neilsen D, Unruh W   +34 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Method and characteristics of band gap of periodic pile row structures based on domain decomposition and nullspace technology

Yantu gongcheng xuebao
Aiming at the problems such as complex structure of displacement function, high calculation cost, and difficulty in waveform fitting caused by the distortion of pile-soil parameters when the traditional energy method is used to solve the band gap of ...
GUO Wenjie 1, LI Jiabao 1, LUO Wenjun 1, 2, HONG Xian 1, XU Changjie 1
doaj   +1 more source

Analysis of a Collision-Energy-Based Method for the Prediction of Ice Loading on Ships

Applied Sciences, 2019
Ships designed for operation in Polar waters must be approved in accordance with the International Code for Ships Operating in Polar Waters (Polar Code), adopted by the International Maritime Organization (IMO).
Sabina Idrissova, Martin Bergström, Spyros E. Hirdaris, Pentti Kujala   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source