Results 101 to 110 of about 2,110,233 (290)
OSeMOSYS-PuLP: A Stochastic Modeling Framework for Long-Term Energy Systems Modeling
Energies, 2019 Recent open-data movements give access to large datasets derived from real-world observations. This data can be utilized to enhance energy systems modeling in terms of heterogeneity, confidence, and transparency. Furthermore, it allows to shift away from
Dennis Dreier, Mark Howells
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Energy modeling to compensate for the seasonal lack of electrical and thermal energy depending on the different climates of Iran. [PDF]
Heliyon, 2023 Ahmadi-Kaliji S +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
EnergiesThe continuous growth of the urban electric vehicles market and the rapid progress of the electronics industry create positive prospects towards fostering the development of autonomous robotic solutions for covering critical production sectors ...
Dimitrios Loukatos +4 more
doaj +1 more source
Net-Zero CO<sub>2</sub> by 2050 Scenarios for the United States in the Energy Modeling Forum 37 Study. [PDF]
Energy Clim Chang, 2023 Browning M +12 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Using urban building energy modeling to quantify the energy performance of residential buildings under climate change. [PDF]
Build Simul, 2023 Deng Z, Javanroodi K, Nik VM, Chen Y.
europepmc +1 more source
, 2012 PUBLISHED In Ireland, the energy sector has undergone significant change in the last forty years. In this period, there has been a significant increase in the demand for energy. This increase has been driven by economic and demographic factors. Although the current deep recession has quelled the upward trend in the demand for energy, a future economic
HYLAND, MARIE, DI COSMO, VALERIA
openaire +2 more sources