Results 81 to 90 of about 30,278,530 (309)
Comparative study of materials for proton exchange membrane fuel cells bipolar plates: Electrical performance, durability, and automotive compatibility [PDF]
EPJ Web of ConferencesBipolar plates are essential components of proton exchange membrane fuel cells because they contribute to current transport, reactant flow distribution, heat dissipation, and overall stack durability.
Elyoubi Meryem +3 more
doaj +1 more source
Energies, 2022 While the contribution of renewable energy technologies to the energy system is increasing, so is its level of complexity. In addition to new types of consumer systems, the future system will be characterized by volatile generation plants that will ...
Alexander Blinn, Henrik te Heesen
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Energies, 2021 The signatory countries of the Paris Agreement must submit their updated Intended National Determined Contributions (INDCs) to the UNFCCC secretariat every five years. In Colombia, this activity was historically carried out with a wide set of diverse non-
Juan David Correa-Laguna +3 more
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Energy Models for Graph Clustering
Journal of Graph Algorithms and Applications, 2007 Summary: The cluster structure of many real-world graphs is of great interest, as the clusters may correspond e.g. to communities in social networks or to cohesive modules in software systems. Layouts can naturally represent the cluster structure of graphs by grouping densely connected nodes and separating sparsely connected nodes.
openaire +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Scientific ReportsInhibition of Cyclooxygenase-2 (COX-2) represents a well-established and promising strategy in the development of anti-inflammatory drugs, given its pivotal role in mediating inflammation. Selective inhibition of COX-2 over COX-1 is critical for reducing
Sonam Grewal +3 more
doaj +1 more source
Engineered ScienceThis study investigates the non-isothermal laminar flow and heat transfer of waxy oil in a pipe with a sudden enlargement, emphasizing its transition from a Newtonian to a viscoplastic state during cooling.
Uzak Zhapbasbayev +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source