Results 111 to 120 of about 2,110,233 (290)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Bandgap energy modeling of the deformed ternary GaAs_1-uN_u by artificial neural networks. [PDF]

Heliyon, 2022
Tarbi A, Chtouki T, Elkouari Y, Erguig H, Migalska-Zalas A, Aissat A.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Triboelectrochemical Performance of Electron Beam–Melted Ti-6Al-4V-ELI for Biomedical Applications

Advances in Materials Science and Engineering
Titanium alloys have been widely used for biomaterials’ production due to their high physicochemical stability, mechanical resistance, and biocompatibility.
E. F. Pieretti, L. C. E. Silva, M. S. Ribeiro, W. de Rossi, R. A. Antunes, M. C. L. Oliveira, D. Piaggio, F. P. A. Cruz, J. O. da Paz, M. D. M. das Neves   +9 more
doaj   +1 more source

Renewable energy targets and unintended storage cycling: Implications for energy modeling. [PDF]

iScience, 2022
Kittel M, Schill WP.
europepmc   +1 more source

Three-state random energy model

Physical Review E
We introduce a spin-1 version of the random energy model with crystal field. Crystal field controls the density of 0 spins in the system. We solve the model in the micro-canonincal ensemble. The model has a spin-glass transition at a finite temperature for all strengths of the crystal field.
null Sumedha, Matteo Marsili
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines. [PDF]

iScience, 2023
Sevrin T, Strasser L, Ternet C, Junk P, Caffarini M, Prins S, D'Arcy C, Catozzi S, Oliviero G, Wynne K, Kiel C, Luthert PJ.   +11 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Distributed Activation Energy Modeling and Py-GC/MS Studies on Pyrolysis of Different Printed Circuit Boards for Resource Recovery. [PDF]

ACS Omega, 2022
Krishna JVJ, Prashanth PF, Vinu R.
europepmc   +1 more source