Results 131 to 140 of about 30,278,530 (309)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines. [PDF]

iScience, 2023
Sevrin T, Strasser L, Ternet C, Junk P, Caffarini M, Prins S, D'Arcy C, Catozzi S, Oliviero G, Wynne K, Kiel C, Luthert PJ.   +11 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effects of Climate Change on Wind Power Generation: A Case Study for the German Bight

Energies
Driven by the demands of climate change mitigation, many countries have begun large-scale electricity production from variable renewables, such as solar PV and wind power.
Reinhold Lehneis
doaj   +1 more source

Distributed Activation Energy Modeling and Py-GC/MS Studies on Pyrolysis of Different Printed Circuit Boards for Resource Recovery. [PDF]

ACS Omega, 2022
Krishna JVJ, Prashanth PF, Vinu R.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Urban building energy modeling – A review of a nascent field

, 2015
Over the past decades, detailed individual building energy models (BEM) on the one side and regional and country-level building stock models on the other side have become established modes of analysis for building designers and energy policy makers ...
C. Reinhart, C. Davila
semanticscholar   +1 more source

Characteristics of Domestic Hot Water Consumption Profiles in Multi-Family Buildings for Energy Modeling Purposes

Energies
This paper presents a domestic hot water (DHW) consumption model for multi-family residential buildings that captures demand variability across monthly, daily, and hourly timescales.
Agnieszka Chmielewska
doaj   +1 more source

The fluctuation analysis of public opinion energy: Modeling social group opinion base on the event of social networks. [PDF]

Intell Syst Appl, 2022
Shi Y, Qi J, Wang R.
europepmc   +1 more source