Results 91 to 100 of about 252,020 (311)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A novel algebraic technique for adjacency matrices of some derived graphs
Mathematical and Computer Modelling of Dynamical SystemsGraph energy has been the main concern of spectral graph theory in the last five decades. The classical graph energy is the sum of the absolute values of the eigenvalues of the adjacency matrix. In many research papers, different versions of graph energy
Hacer Ozden Ayna +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Energy Models for Graph Clustering
Journal of Graph Algorithms and Applications, 2007 Summary: The cluster structure of many real-world graphs is of great interest, as the clusters may correspond e.g. to communities in social networks or to cohesive modules in software systems. Layouts can naturally represent the cluster structure of graphs by grouping densely connected nodes and separating sparsely connected nodes.
openaire +1 more source
On the Laplacian energy of a graph [PDF]
, 1984 summary:In this paper we consider the energy of a simple graph with respect to its Laplacian eigenvalues, and prove some basic properties of this energy.
Cvetković, Dragoš +2 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Graph to Activation Energy Models Easily Reach Irreducible Errors but Show Limited Transferability
, 2023 Activation energy characterization of competing reactions is a costly, but crucial step for understanding the kinetic relevance of distinct reaction pathways, product yields, and myriad other properties of reacting systems.
Qiyuan, Zhao +2 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Explainable cyber-physical energy systems based on knowledge graph
, 2021 Explainability can help cyber-physical systems alleviating risk in automating decisions that are affecting our life. Building an explainable cyber-physical system requires deriving explanations from system events and causality between the system elements.
Fajar Juang Ekaputra +15 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source