Results 111 to 120 of about 4,570,493 (301)

An Experimental and Numerical Investigation of a Passive Façade and Proposals for Improving Its Energy Performance

Energies
The double-skin façade (DSF), referred to hereinafter as a passive façade, represents an alternative technology aimed at improving the energy performance of buildings with glass envelopes. A passive façade consists of a traditional façade supplemented on
Eugen Iavorschi, Laurențiu Dan Milici, Pavel Atănăsoae, Constantin Ungureanu   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Heat Transfer Coefficient of a Building: A Constant with Limited Variability or Dynamically Variable?

Energies
The heat transfer coefficient, or the HTC, is an industry-standard indicator of building energy performance. It is predicated on an assumption that it is of a constant value, and several different methods have been developed to measure and calculate the ...
Ljubomir Jankovic, Grant Henshaw, Christopher Tsang, Xinyi Zhang, Richard Fitton, William Swan   +5 more
doaj   +1 more source

A Detailed Analysis of Contemporary ARM and x86 Architectures [PDF]

, 2013
RISC vs. CISC wars raged in the 1980s when chip area and processor design complexity were the primary constraints and desktops and servers exclusively dominated the computing landscape.
Blem, Emily, Menon, Jaikrishnan, Sankaralingam, Karthikeyan   +2 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Systematic Review of Green Roofs’ Thermal and Energy Performance in the Mediterranean Region

Energies
Due to ongoing climate change, urban areas face increasing challenges associated with rising temperatures and growing energy demand. Green roofs have emerged as a sustainable, nature-based solution to enhance urban resilience.
Edoardo De Cristo, Luca Evangelisti, Leone Barbaro, Roberto De Lieto Vollaro, Francesco Asdrubali   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Energy Performance and Thermal Comfort in Madrid School Buildings Under Climate Change Scenarios

Applied Sciences
This study presents a detailed analysis of the energy performance and thermal comfort conditions in four existing school buildings located in Madrid, Spain.
Violeta Rodríguez-González, María del Mar Barbero-Barrera   +1 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source