Results 121 to 130 of about 1,600,946 (312)

Heat Transfer Coefficient of a Building: A Constant with Limited Variability or Dynamically Variable?

Energies
The heat transfer coefficient, or the HTC, is an industry-standard indicator of building energy performance. It is predicated on an assumption that it is of a constant value, and several different methods have been developed to measure and calculate the ...
Ljubomir Jankovic, Grant Henshaw, Christopher Tsang, Xinyi Zhang, Richard Fitton, William Swan   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Systematic Review of Green Roofs’ Thermal and Energy Performance in the Mediterranean Region

Energies
Due to ongoing climate change, urban areas face increasing challenges associated with rising temperatures and growing energy demand. Green roofs have emerged as a sustainable, nature-based solution to enhance urban resilience.
Edoardo De Cristo, Luca Evangelisti, Leone Barbaro, Roberto De Lieto Vollaro, Francesco Asdrubali   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An Integrated Approach to Energy Harvester Modeling and Performance Optimization

, 2007
This paper proposes an integrated approach to energy harvester (EH) modeling and performance optimization where the complete mixed physical-domain EH (micro generator, voltage booster, storage element and load) can be modeled and optimized.
Beeby, Steve, Torah, Russel, Wang, Leran, Bashir M. Al-Hashimi, Kazmierski, Tom, Al-Hashimi, Bashir, Steve P. Beeby, Leran Wang, Tom J. Kazmierski, Russel N. Torah   +9 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Energy Performance and Thermal Comfort in Madrid School Buildings Under Climate Change Scenarios

Applied Sciences
This study presents a detailed analysis of the energy performance and thermal comfort conditions in four existing school buildings located in Madrid, Spain.
Violeta Rodríguez-González, María del Mar Barbero-Barrera   +1 more
doaj   +1 more source

Optimal balance between energy demand and onsite energy generation for robust net zero energy buildings considering future scenarios [PDF]

, 2015
Net-zero energy buildings have usually very low energy demand, and consequently heating ventilation and air conditioning (HVAC) systems are designed and controlled to meet this low energy demand.
Hoes, P Pieter-Jan, Hensen, J.L.M., Kotireddy, R.R., Hoes, P.; id_orcid, Kotireddy, RR Rajesh, Hoes, P., Hensen, JLM Jan   +6 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

PDCA-Based Methodology for the Evaluation of Energy Efficiency in the Industrial Sector

Applied Sciences
Reducing energy consumption and improving energy efficiency are essential objectives in the productive sector to ensure economic growth and reduce emissions. However, some energy management models do not include tools such as the balanced scorecard (BSC)
Luis Vargas-Gurrola, Quetzalli Aguilar-Virgen, Silvia Balderas-López, Paul Taboada-González   +3 more
doaj   +1 more source