Results 111 to 120 of about 1,600,946 (312)

Energy Performance And Long-Term Evaluation Of Internal Thermal Comfort Of An Office Building With Different Kinds Of Glazing Systems And Window Sizes

, 2012
Although the presence of large window surfaces could be preferable during the heating season when solar gains through the glazed components can overcome heating losses from the same surfaces, during the cooling season more attention has to be paid in ...
Gasparella, Andrea, Pernigotto, Giovanni, Giovanni PERNIGOTTO, Romagnoni, Piercarlo, Andrea GASPARELLA, Cappelletti, Francesca   +5 more
core  

Clustering energy performance certificates : a methodology for selecting representative buildings in scalable energy simulations

Publisher Copyright: © 2025 The Author(s).This study presents a methodology for selecting representative buildings through clustering of Energy Performance Certificate (EPC) features.
Leiber, Collin, Mannila, Heikki, Hajian, Hatef, Ferrantelli, Andrea, Härkönen, Kalevi   +4 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Energy performance assessment and HVAC system sizing in a multi-era hospital complex: the case of Policlinico Sant’Orsola

reservedThis thesis presents an energy performance analysis and HVAC systems sizing of selected pavilions at the Sant’Orsola-Malpighi Polyclinic in Bologna, Italy.
FAZELI, MASOUD
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An Experimental and Numerical Investigation of a Passive Façade and Proposals for Improving Its Energy Performance

Energies
The double-skin façade (DSF), referred to hereinafter as a passive façade, represents an alternative technology aimed at improving the energy performance of buildings with glass envelopes. A passive façade consists of a traditional façade supplemented on
Eugen Iavorschi, Laurențiu Dan Milici, Pavel Atănăsoae, Constantin Ungureanu   +3 more
doaj   +1 more source

Roof Integrated Solar Absorbers: The Measured Performance of ''Invisible'' Solar Collectors: Preprint [PDF]

, 2001
The Florida Solar Energy Center (FSEC), with the support of the National Renewable Energy Laboratory, has investigated the thermal performance of solar absorbers that are an integral, yet indistinguishable, part of a building's roof.
Colon, C. J. (Florida Solar Energy Center), Merrigan, T. (National Renewable Energy Laboratory)   +1 more
core  

A methodology for equitable performance assessment and presentation of wave energy converters based on sea trials

, 2013
A general and widely applicable methodology to assess and present the performance of wave energy converters (WEC) based on sea trials is presented.
Kofoed, Jens Peter, Berthelsen, Kasper Klitgaard, Berthelsen, K, Neumann, E, Johnstone, C., Le Crom, I, McCombes, Tom, Holmes, B., Retzler, Chris, Antonishen, Michael Patrick, Johnstone, Cameron, Le Crom, I., Neumann, F., Pecher, Arthur, Holmes, Brian, Antonischen, M, Bittencourt, Claudio, Myers, L.E., Margheritini, Lucia, McCombes, T., Margheritini, L, Retzler, C.   +21 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source