Results 71 to 80 of about 452,384 (268)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluating the Trade-Off Between Energy Efficiency and Energy Saving in Spray Drying Operations

Gazi Üniversitesi Fen Bilimleri Dergisi
In this study, modelling simulations were employed to analyze the effects of inlet drying air flow rate and temperature, product feed rate, and heat recovery ratio in a spray dryer.
Gülşah Karaca Dolgun
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Research on the evolution characteristics of creep energy in rubber concrete and the damage constitutive model

Scientific Reports
To investigate the evolution law of energy and the damage constitutive model of concrete with different rubber replacement ratios under uniaxial creep, this paper systematically studied the creep energy evolution law of rubber concrete using uniaxial ...
Xiaodie Liu, Lei Cui, Zhixi Liu
doaj   +1 more source

Behavior of higher-order MDD on energy ratios at the interface of thermoelastic and piezothermoelastic mediums. [PDF]

Sci Rep, 2023
Barak MS, Ahmad H, Kumar R, Kumar R, Gupta V, Awwad FA, Ismail EAA.   +6 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Assessment of energy metabolism and methane emission in cattle and buffaloes fed TMR diets having different concentrate to roughage ratios

Indian Journal of Animal Sciences, 2014
India has the largest livestock population and ruminants are one of the main contributors of methane production i.e. about 20% of the total CH4 emission.
A K SINGH, V B CHATURVEDI, P SINGH, A K VERMA, L C CHAUDHARY, T MANDAL   +5 more
doaj   +1 more source

Dietary protein to starch metabolizable energy ratios alter growth performance and gastrointestinal microbiota of calves. [PDF]

Front Microbiol, 2023
Chen X, Han Z, Dong J, Xiao J, Zhao W, Rong J, Aschalew ND, Zhang X, Qin G, Zhen Y, Sun Z, Wang T.   +11 more
europepmc   +1 more source